We designed an association (retrospective, case control) study aimed at evaluating associations between genetic variations of the human apolipoprotein B (apoB) gene and clinical diagnosis of essential hypertension. Our approach was to compare the distribution of the alleles of a highly polymorphic variable number of tandem repeats localized 3' to the human apoB gene, the apoB 3' hypervariable r...

Hepatitis C virus (HCV) populations in vivo consist of heterogeneous mixtures of genetically different but closely related variants defined as a 'quasispecies'. The longitudinal fluctuation of HCV quasispecies populations in chronic hepatitis C has not been elucidated. Serial plasma samples were obtained from four patients with chronic hepatitis C (two patients without any treatment and two pat...

Potential adverse effects on the O2-sensing function of the carotid body when its cells are exposed to toxic O2 pressures were assessed during investigations of human organ tolerance to prolonged continuous and intermittent hyperoxia (Predictive Studies V and VI). Isocapnic hypoxic ventilatory responses (HVR) were determined at 1.0 ATA before and after severe hyperoxic exposures: 1) continuous ...

Denaturing gradient gel electrophoresis (DGGE) was used to study the diversity of hepatitis C virus (HCV) quasispecies. Optimized DGGE running conditions were applied to screen for variations in sequences cloned from amplicons originating from the nonstructural 5b (NS5b) gene of HCV in blood of hemophilia patients, intravenous drug users, and blood donors (five specimens from each study group, ...

در سال‌های أخیر با افزایش پیچیدگی، سطح عدم­اطمینان نیز یافته است؛ ازاین‌رو مدیریت ریسک زنجیره تأمین یکی از موضوع‌هایی است که موردتوجه سازمان‌ها قرار گرفته است. ریسک‌های موجود تأمین، وارده ناحیه تأمین‌کنندگان پژوهش حاضر به‌کارگیری مدلی به‌منظور ارزیابی صنایع غذایی شی­‌فو، به شناسایی محتمل و اتخاذ تصمیماتی راستای می­‌پردازد. مدل به‌کار‌گرفته‌شده، ترکیبی محاسبات کلامی فازی (FLC) محاسبه مقدار عوامل...

به منظور ساخت، راه‌اندازی و عیب‌یابی مقدماتی چشمه پنینگ داخلی سیکلوترون 10IRANCYC، یک مگنت الکتریکی دوقطبی با میدان مغناطیسی در حد امکان مشابه مرکز مذکور طراحی ساخته شد. این الکترومگنت که دانشکده فیزیک دانشگاه تهران شد، قادر است بزرگی 7000 گوس را محل استقرار (منطقه‌­ای شعاع 15 میلی‌متر مگنت) آسانی بدون نیاز خنک‌سازی تأمین کند. دست‌­یابی 1/1 تسلا نیز استفاده از برای مدت چند دقیقه امکان‌­پذیر است...

The aim of this study was to investigate the association between apolipoprotein B gene polymorphisms and coronary artery disease and lipid levels in north Indians. Two hundred patients of angiographically proven atherosclerotic CAD and two hundred age and sex matched control subjects were included in the study. Serum lipids including cholesterol, triglycerides, HDL, LDL, VLDL and ApoB were anal...

Vaccination is an essential component in controlling infectious bursal disease (IBD), however, there a lack of information on the genetic characteristics recent virus (IBDV) that was isolated from IBD vaccinated commercial flocks Malaysia. The present study investigated 11 IBDV isolates were poultry farms. detected using reverse transcription-polymerase chain reaction (RT-PCR) targeting hyperva...

OPIOID-INDUCED RESPIRATORY depression (OIRD) is a serious public health and patient safety concern. In 2010, drug overdose was the leading cause of injury death in the United States (32), with 75% of these deaths involving opioid analgesics (2, 10). The problem is not limited to outpatients: severe respiratory depression and death occur even in hospitals using closedloop administration devices ...