نتایج جستجو برای: مولکول های گیرنده شبه زنگوله ای tlr2

تعداد نتایج: 515137  

Journal: :Journal of immunology 2002
Osamu Takeuchi Shintaro Sato Takao Horiuchi Katsuaki Hoshino Kiyoshi Takeda Zhongyun Dong Robert L Modlin Shizuo Akira

The Toll-like receptor (TLR) family acts as pattern recognition receptors for pathogen-specific molecular patterns (PAMPs). TLR2 is essential for the signaling of a variety of PAMPs, including bacterial lipoprotein/lipopeptides, peptidoglycan, and GPI anchors. TLR6 associates with TLR2 and recognizes diacylated mycoplasmal lipopeptide along with TLR2. We report here that TLR1 associates with TL...

ژورنال: مواد نوین 2015

در این مقاله نانوذرات مغناطیسی اکسید آهن باروش هم­رسوبی سنتز شده و سطح آن به وسیله مولکول 2- آمینو       5- مرکاپتو1، 3، 4- تیا دیا­زول اصلاح شد و برای حذف رنگ آلی آبی نیل از آب های آلوده مورد بررسی قرارگرفت. نانوذرات به کمک روش­های دستگاهی XRD، FT-IR، TEM و آنالیز عنصری شناسایی شدند. مکانیسم و فاکتورهای موثر بر فرایند جذب مانند اثر زمان، pH و غلظت جاذب مؤثر بر جذب به روش دسته­ای مورد بررسی قرا...

Journal: :Molecular medicine reports 2014
Chang-Hwan Kim Dong-Jae Kim Sang-Jin Lee Yu-Jin Jeong Min-Jung Kang Jun-Young Lee Jin-A Choi Sun-Jung Kwon Jae-Hak Park Jong-Hwan Park

Toll‑like receptor 2 (TLR2) has been identified as a sensor for bacterial lipoprotein. To determine the role of TLR2 in host defense against Acinetobacter baumannii infection, wild‑type (WT) and TLR2‑deficient mice were infected intranasally with A. baumannii. Body weight, cytokine and chemokine levels in bronchoalveolar (BAL) fluid and lung histopathology were examined. Body weight changes in ...

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه پیام نور - دانشگاه پیام نور استان تهران - دانشکده علوم پایه 1388

به دست آوردن پاسخ های تحلیلی معادلات موج در مکانیک کوانتومی به دلیل اهمیت این پاسخ ها در افزایش درک مفهومی ما از پدیده های فیزیکی حائز اهمیت بسیار می باشند. از سوی دیگر به دست آوردن پاسخ های معادله ی شرودینگر برای پتانسیل های با تقارن کروی در ابعاد دلخواه فضایی از همان روزهای آغازین پیدایش مکانیک کوانتومی غیر نسبیتی در کانون توجه بوده است. با وجود این که مدل نوسانگر هماهنگ ساده به صورت گسترده ا...

Journal: :Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2011
Ute Hoffmann Tobias Bergler Munhie Rihm Claudia Pace Bernd Krüger Bettina Jung Stephan W Reinhold Stefan Farkas Petra Rümmele Bernhard K Krämer Bernhard Banas

BACKGROUND An important role of TLR2 has been shown in various experimental models of renal ischaemia/reperfusion injury. To study the expression of TLR2 in renal allograft rejection systematically, we established an experimental rat transplantation model. METHODS TLR2 expression was analysed in 99 human renal allograft biopsies, and in rat allografts at Day 6 and 28 after experimental renal ...

Journal: :American journal of physiology. Lung cellular and molecular physiology 2008
K L Bailey J A Poole T L Mathisen T A Wyatt S G Von Essen D J Romberger

Hog confinement workers are at high risk to develop chronic bronchitis as a result of their exposure to organic dust. Chronic bronchitis is characterized by inflammatory changes of the airway epithelium. A key mediator in inflammation is Toll-like receptor 2 (TLR2). We investigated the role of TLR2 in pulmonary inflammation induced by hog confinement dust. Normal human bronchial epithelial cell...

Journal: :Journal of immunology 2011
Hye Sung Kim Heounjeong Go Shizuo Akira Doo Hyun Chung

Idiopathic pulmonary fibrosis is a fatal disease characterized by progressive destruction of the lung. Although TLR2 bridges innate and adaptive immunity by sensing tissue damage, its role in pulmonary fibrosis remains unclear. To address this issue, TLR2(-/-) and WT mice were examined for bleomycin-induced pulmonary fibrosis (BIPF). Flow cytometric and immunohistochemical analysis revealed tha...

Journal: :Journal of immunology 2000
T Wang W P Lafuse B S Zwilling

Recent studies have implicated Toll-like receptors (TLR), especially TLR2 and TLR4, as sentinel receptors that signal the interaction of macrophages with bacterial pathogens via a NF-kappaB-mediated pathway. The regulation of TLR gene expression, however, has not been intensively studied. Here, we report that TLR2 mRNA was induced following infection of murine macrophages with Mycobacterium avi...

Journal: :Veterinary research 2006
Masanori Tohno Takeshi Shimosato Masayuki Moue Hisashi Aso Kouichi Watanabe Yasushi Kawai Takahiro Yamaguchi Tadao Saito Haruki Kitazawa

To clarify the crucial role of Toll-like receptor (TLR) 2 and TLR9 in immature gut-associated lymphoid tissues (GALT), we focused on the expression of TLR2 and TLR9 and the immune responses induced by their ligands in the GALT of presuckling newborn swine. Quantitative real-time PCR revealed that TLR2 and TLR9 mRNA were expressed at detectable levels in all tested tissues (heart, thymus, lung, ...

Journal: :Journal of immunology 2006
Heather J Brown Helen R Lock Steven H Sacks Michael G Robson

Infection may exacerbate organ-specific autoimmune disease such as glomerulonephritis. This may occur in the absence of a measurable effect on the adaptive immune response, and the mechanisms responsible are not fully understood. To investigate this, we have studied the effect of TLR2 ligation by the synthetic ligand Pam(3)CysSK(4) on the development of glomerulonephritis in mice. We demonstrat...

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