The anti-Tac mAb has been shown to bind to the p55 chain of the IL-2R, block IL-2 binding and inhibit T cell proliferation. A humanized form of anti-Tac (HAT) has been constructed that retains the binding properties of murine anti-Tac (MAT). These two mAb were evaluated in cynomolgus monkeys to compare relative immunogenicity and pharmacokinetic properties. Monkeys treated with HAT daily for 14...

Let $f$ be a locally univalent function on the unit disk $U$. We consider the normalized extensions of $f$ to the Euclidean unit ball $B^nsubseteqmathbb{C}^n$ given by $$Phi_{n,gamma}(f)(z)=left(f(z_1),(f'(z_1))^gammahat{z}right),$$  where $gammain[0,1/2]$, $z=(z_1,hat{z})in B^n$ and $$Psi_{n,beta}(f)(z)=left(f(z_1),(frac{f(z_1)}{z_1})^betahat{z}right),$$ in which $betain[0,1]$, $f(z_1)neq 0$ a...