We evaluated the in vitro activity of the new echinocandin antifungal micafungin against Candida spp. using microdilution and time-kill methods. Additionally, we examined the postantifungal effect (PAFE) of micafungin. Finally, we evaluated the effect of the addition of serum and plasma on the MIC of micafungin. Four Candida albicans isolates and two isolates of each Candida glabrata, Candida k...

OBJECTIVES The aim of this study was to assess the in vitro activities of nemonoxacin against Gram-positive cocci with various resistance phenotypes. METHODS MICs of nemonoxacin were determined for 798 recently collected (2005-07) and non-duplicate isolates of Gram-positive cocci by the agar dilution method. These isolates included: methicillin-susceptible Staphylococcus aureus (MSSA; n = 100...

Pancreatic cancer (PC) is the fourth leading cause of cancer-related mortality in the United States. There is no effective serum biomarker for the early diagnosis of PC at present. Although serum UL16-binding protein 2 (ULBP2) and macrophage inhibitory cytokine-1 (MIC-1) levels are reported to be elevated in PC patients, the diagnostic and prognostic value of ULBP2 and MIC-1 alone or in combina...

In this paper, a Many Integrated Core Architecture (MIC) accelerated parallel method of moment (MoM) algorithm is proposed to solve electromagnetic problems in practical applications, where MIC means a kind of coprocessor or accelerator in computer systems which is used to accelerate the computation performed by Central Processing Unit (CPU). Three critical points are introduced in this paper i...

We describe a database named MIC database containing 2-dimensional structures of synthesized compounds/antibiotics, IUPAC name, smiles notation and the MIC values / zone of inhibition against a particular organism, strain and culture conditions. The data was collected from various literature sources such as Arkivoc, Bioorganic Medicinal Chemistry Letters, Antimicrobial Agents and Chemotherapy, ...

PURPOSE Optimal dosing of antibiotics is important for efficacy and avoidance of resistance. Fluoroquinolones are frequently used to treat severe infections in critically ill patients. We studied ciprofloxacin pharmacokinetics after administration of 400 mg twice a day (bid) intravenously (IV). MATERIAL AND METHODS Serum concentrations were measured in 32 intensive care unit patients (age, 68...

1048 tericidal activity of ceftazidime could be correlated with the MIC value for the different strains. Results when the strains were exposed to a concentration of 4 × MIC were comparable to those at 8 × MIC, suggesting that no further bactericidal effect can be achieved by increasing the ceftazidime concentration above 4 × MIC (no concentration effect). At 2 × MIC, bactericidal activity was s...