نتایج جستجو برای: مسیر ras

تعداد نتایج: 54191  

Journal: :Current Biology 2010
Lizhong Xu Veronica Lubkov Laura J. Taylor Dafna Bar-Sagi

Ras proteins play a central role in transducing signals that control cell proliferation, differentiation, motility, and survival. The location-specific signaling activity of Ras has been previously shown to be regulated by ubiquitination [1]. However, the molecular machinery that controls Ras ubiquitination has not been defined. Here we demonstrate through biochemical and functional analyses th...

2002
Kwanghee Kim Mary J. Lindstrom Michael N. Gould

Organ-specific cancers with activated ras oncogenes most often are associated exclusively with only one ras isoform. For example, only H-ras activation is associated with rat mammary cancers. The mechanism underlying this specificity is mostly unknown. We have shown previously that this tissue specificity of Ras isoforms is defined by the Ras protein itself and not by differential gene expressi...

Journal: :گوارش 0
abbas yazdanbod rasoul nemati manouchehr iranparvar alamdari ahad azami nasrollah maleki

background : â  celiac disease (cd) is an immune-mediated inflammation of the small intestine caused by sensitivity to dietary gluten and related proteins in genetically sensitive individuals . recurrent aphthous stomatitis (ras) is an inflammatory condition characterized by painful recurrent, single or multiple ulcerations of the oral mucosa. the association between cd and ras has been evaluat...

Journal: :Cancer research 2003
Duk-Hwan Kim Jin Seuk Kim Jung-Ho Park Suk Kyoo Lee Yong-Ick Ji Young Mi Kwon Young Mog Shim Joungho Han Joobae Park

Recently, several groups have reported that Ras association domain family 1 (RASSF1A) interacts with Ras and mediates Ras-dependent apoptosis. However, the mechanism by which RASSF1A plays a role as a tumor suppressor in human cancer is unclear. In this study, we investigated the relationship between the RASSF1A methylation and K-ras mutation and their effects on patient's survival in 242 prima...

2015
Alpana Ray Bimal K Ray

In the majority of breast cancers, overexpression and hyperactivation of Ras in the tumor microenvironment play significant role in promoting cancer cell growth, angiogenesis, and metastasis. We have previously shown that vascular endothelial growth factor (VEGF) expression in triple negative breast cancer cells is regulated, at least in part, by SAF-1 (serum amyloid A activating factor 1) tran...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2015
Maud H W Starmans Melania Pintilie Michelle Chan-Seng-Yue Nathalie C Moon Syed Haider Francis Nguyen Suzanne K Lau Ni Liu Arek Kasprzyk Bradly G Wouters Sandy D Der Frances A Shepherd Igor Jurisica Linda Z Penn Ming-Sound Tsao Philippe Lambin Paul C Boutros

PURPOSE While the dysregulation of specific pathways in cancer influences both treatment response and outcome, few current prognostic markers explicitly consider differential pathway activation. Here we explore this concept, focusing on K-Ras mutations in lung adenocarcinoma (present in 25%-35% of patients). EXPERIMENTAL DESIGN The effect of K-Ras mutation status on prognostic accuracy of exi...

Journal: :Cancer research 1994
R Mangues J M Kahn I Seidman A Pellicer

The induction of tumors with chemicals and the production of transgenic animals are two experimental approaches to study oncogene involvement in carcinogenesis. The combination of both strategies offers an excellent model system to study tumor development. This study analyzes the potential cooperation of N-methylnitrosourea (MNU) treatment and N-ras proto-oncogene overexpression in tumorigenesi...

Journal: :Development 2010
Taeko Ichise Nobuaki Yoshida Hirotake Ichise

Mammalian Ras, which is encoded by three independent genes, has been thought to be a versatile component of intracellular signalling. However, when, where and how Ras signalling plays essential roles in development and whether the three Ras genes have overlapping functions in particular cells remain unclear. Here, we show that the three Ras proteins dose-dependently regulate lymphatic vessel gr...

Journal: :Cancer research 2015
Saori Fujita-Sato Jacqueline Galeas Morgan Truitt Cameron Pitt Anatoly Urisman Sourav Bandyopadhyay Davide Ruggero Frank McCormick

Oncogenic K-Ras mutation occurs frequently in several types of cancers, including pancreatic and lung cancers. Tumors with K-Ras mutation are resistant to chemotherapeutic drugs as well as molecular targeting agents. Although numerous approaches are ongoing to find effective ways to treat these tumors, there are still no effective therapies for K-Ras mutant cancer patients. Here we report that ...

Journal: :Cancer research 2002
Kwanghee Kim Mary J Lindstrom Michael N Gould

Organ-specific cancers with activated ras oncogenes most often are associated exclusively with only one ras isoform. For example, only H-ras activation is associated with rat mammary cancers. The mechanism underlying this specificity is mostly unknown. We have shown previously that this tissue specificity of Ras isoforms is defined by the Ras protein itself and not by differential gene expressi...

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