BACKGROUND AND PURPOSE High tumor interstitial fluid pressure (IFP) is associated with poor outcome in locally advanced carcinoma of the uterine cervix. We have recently developed a noninvasive assay of the IFP of tumors, and in this assay, the outward interstitial fluid flow velocity at the tumor surface (v0) is measured by Gd-DTPA-based DCE-MRI and used as a parameter for IFP. Here, we invest...

Cancer therapies using genes and other macromolecules might realize their full clinical potential if they could be delivered to tumor tissue in optimal quantities. Unfortunately, the compromised circulation within tumors poses a formidable resistance to adequate and uniform penetration of these agents. Previously, we have proposed elevated interstitial fluid pressure (IFP) as a major physiologi...

Numerical Modeling of Thermal EOR: Comprehensive Coupling of an AMR-Based Model of Thermal Fluid Flow and Geomechanics — Modeling Steam Assisted Gravity Drainage (SAGD) can involve significant CPU (Central Processing Unit) time when both thermal fluid flow and geomechanics are coupled in order to take into account variations of permeability and porosity inside the reservoir due to stress change...

Many cryptosystems suffer from fault attacks when implemented in physical devices such as smart cards. Fault attacks on secret key elements have successfully targeted many protocols relying on the Elliptic Curve Discrete Logarithm Problem (ECDLP), the Integer Factorization Problem (IFP) or the Discrete Logarithm Problem (DLP). More recently, faults attacks have also been designed against the pu...

INTRODUCTION Vanek's tumour or Inflammatory Fibroid Polyp (IFP) are rare, benign localised lesions originating from the sub-mucosa of the gastrointestinal tract (GI) tract.(1) They have been widely reported as occurring within the stomach, Duodenum, Jejunum and Ileum, more rarely (<1%) in the caecum or appendix. PRESENTATION OF CASE We present a case of a 28-year-old lady who presented with a...

Stroma properties affect carcinoma physiology and direct malignant cell development. Here we present data showing that α(V)β(3) expressed by stromal cells is involved in the control of interstitial fluid pressure (IFP), extracellular volume (ECV) and collagen scaffold architecture in experimental murine carcinoma. IFP was elevated and ECV lowered in syngeneic CT26 colon and LM3 mammary carcinom...

Normal Stresses and Interface Displacement: Influence of Viscoelasticity on Enhanced Oil Recovery Efficiency — One of chemical Enhanced Oil Recovery (EOR) methods consists in injecting aqueous solutions of polymers into the reservoir in order to improve mobility ratio between the injected fluid and the remaining oil. This “polymer flooding” process is usually only characterized with the low she...

Patient reported outcome measures (PROMs) were introduced in 2009 to allow patient perspectives to potentially influence change and improvement. In collaboration with the national joint registry (NJR), PROMs data has been examined on a national basis to compare surgical factors in total knee replacement (TKR). Initial results demonstrated there were statistically significant differences in Oxfo...