Differentiation of the bipotential gonad into testis is initiated by the Y chromosome-linked gene SRY (Sex-determining Region Y) through upregulation of its autosomal direct target gene SOX9 (Sry-related HMG box-containing gene 9). Sequence and chromosome homology studies have shown that SRY most probably evolved from SOX3, which in humans is located at Xq27.1. Mutations causing SOX3 loss-of-fu...

Although the disorder of sex development in dogs with female karyotype (XX DSD) is quite common, its molecular basis is still unclear. Among mutations underlying XX DSD in mammals are duplication of a long sequence upstream of the SOX9 gene (RevSex) and duplication of the SOX9 gene (also observed in dogs). We performed a comparative analysis of 16 XX DSD and 30 control female dogs, using FISH a...

OBJECTIVE To develop a mathematical model for more precise estimation of the incidence of chromosomal abnormalities and the sex ratio among spontaneous abortions masked by maternal cell contamination. DESIGN Retrospective analysis. SETTING Academic medical center. PATIENT(S) One hundred twelve samples of spontaneous abortion with a "46,XX" karyotype and 97 parents with aborted embryos. ...

Using genetic and cytogenetic markers, we assessed early development and X-chromosome inactivation (X-inactivation) in XX mouse androgenones produced by pronuclear transfer. Contrary to the current view, XX androgenones are capable of surviving to embryonic day 7.5, achieving basically random X-inactivation in all tissues including those derived from the trophectoderm and primitive endoderm tha...

The third-order nonlinear dispersion PDE, as the key model, (0.1) ut = (uux)xx in R × R+, is studied. Two Riemann’s problems for (0.1) with initial data S∓(x) = ∓signx, create the shock (u(x, t) ≡ S−(x)) and smooth rarefaction (for data S+) waves, [18]. The concept of “δ-entropy” solutions (a“δ-entropy test”) and others are developed for distinguishing shock and rarefaction waves by using stabl...

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We study incentive provision in a model of securities issuance with an informed issuer and uninformed investors. We show that the presence of an informed intermediary may increase surplus even if we allow for collusion between the intermediary and the issuer. Collusion is neutralized by introducing a misalignment between the interests of the issuer and those of the intermediary. To achieve this...

ion refinement techniques in probabilistic model checking are prominent approaches to the verification of very large or infinite-state probabilistic concurrent systems. At the core of the refinement step lies the implicit or explicit analysis of a counterexample. This paper proposes an abstraction refinement approach for the probabilistic computation tree logic (PCTL), which is based on increme...

We diagonalize the XX model with a finite number of spins and periodic boundary conditions. We solve for the ground state, focus on the rapidity of the convergence to the thermodynamic limit and study the features of multipartite entanglement.

To investigate whether sex chromosome complement modulates bradycardic baroreflex response and contributes to the angiotensin II-bradycardic baroreflex sex differences, we used the four core genotype mouse model in which the effect of gonadal sex and sex chromosome complement is dissociated, allowing comparisons of sexually dimorphic traits among XX and XY females, as well as in XX and XY males...