Thanks you very much for submitting your study on DPY30 in regulating cellular senescence for consideration to The EMBO Journal editorial office. Once more, apologies for the slight delay in providing comments, still caused by the recent holiday season. You will easily recognize that the referees are in principle supportive of the data. They do provide however very constructive comments to broa...

BIOPHYSICS AND COMPUTATIONAL BIOLOGY Correction for “Structural defects and the diagnosis of amyloidogenic propensity,” by Ariel Fernández, József Kardos, L. Ridgway Scott, Yuji Goto, and R. Stephen Berry, which appeared in issue 11, May 27, 2003, of Proc Natl Acad Sci USA (100:6446–6451; first published May 12, 2003; 10.1073/ pnas.0731893100). The undersigned authors note the following: “We wi...

PURPOSE Apurinic/apyrimidinic endonuclease 1/redox factor-1 (APE1/Ref-1) is a multifunctional protein that shows elevated expression in a number of cancers. We attempted to determine whether serum APE1/Ref-1 is elevated in patients with bladder cancer. MATERIALS AND METHODS Serum APE1/Ref-1 levels were determined using enzyme-linked immunosorbent assay in serum from patients with bladder canc...

The human DNA repair protein apurinic/apyrimidinic endonuclease (APE) is a dual-function protein that has important roles in both the repair of baseless sites that arise in DNA and in regulating the redox state of a number of proteins (Ref-1). Although previous attention has been focused on how the human APE/Ref-1 gene may be regulated at the DNA level, we have instead examined if APE/Ref-1 is ...

Given a double cover $\pi: \mathcal{G} \rightarrow \hat{\mathcal{G}}$ of finite groupoids, we explicitly construct twisted loop transgression maps, $\tau_{\pi}$ and $\tau_{\pi}^{ref}$, thereby associating to Jandl $n$-gerbe $\hat{\lambda}$ on $\hat{\mathcal{G}}$ $(n-1)$-gerbe $\tau_{\pi}(\hat{\lambda})$ the quotient groupoid $\mathcal{G}$ an ordinary $\tau^{ref}_{\pi}(\hat{\lambda})$ unoriented...

To understand the biological transport and utilization of dioxygen at the level of mechanistic chemistry it has been necessary to synthesize small molecules (active site sections) which carry out the binding or catalytic function. We have prepared iron porphyrin compounds which mimic the dioxygen binding to myoglobin and the oxidations catalyzed by peroxidases and related enzymes. Using a combi...

i) BB16 (1) provide no evidence that J15’s (2) cost, demand flexibility, or electrification assumptions are aggressive. Further, J15’s cost ranges are neither confidence intervals nor narrow (e.g., underground storage capital costs span over an order of magnitude), and, by far, most technologies proposed are commercial or extant for years. ii) BB16 (1) provide no evidence that J15’s (2) results...

In the above article [1] , ref-type="disp-formula" rid="deqn116" xmlns:xlink="http://www.w3.org/1999/xlink">equations (116) and rid="deqn122" xmlns:xlink="http://www.w3.org/1999/xlink">(122) appeared with errors. The correct equations affected text foll...

The weak polymorphic type system of Standard ML of New Jersey (SML/NJ) (MacQueen, 1992) has only been presented as part of the implementation of the SML/NJ compiler, not as a formal type system. As a result, it is not well understood. And while numerous versions of the implementation have been shown unsound, the concept has not been proved sound or unsound. We present an explanation of weak pol...

در آشکار‌ساز CMS نسبت‌های انشعاب بوزون هیگز مدل استاندارد به جفت‌‌های J/ψ(1S) و cc ترتیب برابر 2-10×1/8 2-10×2/89 اندازه‌گیری شده است. لحاظ نظری یکی از سناریوهای ممکن برای تولید مستقیم این است که آغاز جفت واپاشی نماید سپس مرحله‌ی بعد هر یک کوارک‌های c طور مزون ترکش کنند. بر اساس سناریو مقاله بطریق کوارک‎های با استفاده نظریه اختلال مکانیک کوانتومی رنگ (pQCD) نظر گرفتن حالت‌های قطبش طولی عرضی محا...