نتایج جستجو برای: مدل lim
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The three-dimensional solution structure of the 1:1 complex between the synthetic peptide ZF-1 and zinc was determined by 1H NMR spectroscopy. The peptide, initially isolated from pig intestines, is identical in sequence to the 30 N-terminal amino acid residues of the human protein Lasp-1 belonging to the LIM domain protein family. The final set of 20 energy-refined NMR conformers has an averag...
otor neurons located at different positions in the emryonic spinal cord innervate distinct targets in the , establishing a topographic neural map. The organization of motor projections dee generation of subclasses of motor neuect specific paths to their targets. We have cloned a family of LIM homeobox genes in chick and show here that the combinatorial expression of four of these genes, Islet-l...
Serum response factor (SRF) regulates transcription of many serum-inducible and muscle-specific genes. Using a functional screen, we identified LIM kinase-1 as a potent activator of SRF. We show that SRF activation by LIM kinase-1 is dependent on its ability to regulate actin treadmilling. LIM kinase activity is not essential for SRF activation by serum, but signals depend on alterations in act...
Liquid transportation without employing a bulky power source, often observed in nature, has been an essential prerequisite for smart applications of microfluidic devices. In this report, a leaf-inspired micropump (LIM) which is composed of thermo-responsive stomata-inspired membrane (SIM) and mesophyll-inspired agarose cryogel (MAC) is proposed. The LIM provides a durable flow rate of 30 μl/h ·...
مدل سازی و حل مساله مسیریابی وسایل نقلیه (VRP) در بخش توزیع زنجیره تامین با درنظر گرفتن محدودیت تردد
We study direct limits (G,K) = lim −→ (Gn,Kn) of compact Gelfand pairs. First, we develop a criterion for a direct limit representation to be a multiplicityfree discrete direct sum of irreducible representations. Then we look at direct limits G/K = lim −→ Gn/Kn of compact riemannian symmetric spaces, where we combine our criterion with the Cartan–Helgason theorem to show in general that the reg...
LIM proteins constitute a superfamily characterized by the presence of a LIM domain, known to be involved in protein-protein interactions. Our previous work has implicated members of the Zyxin family of LIM proteins, namely TRIP6 and LPP, in the repression of the DNA damage response (DDR) at telomeres. Here, we describe a role for Ajuba, a closely related LIM molecule, in repressing the ATR-med...
The emergence of tumor resistance to conventional microtubule-targeting drugs restricts their clinical use. Using a cell-based assay that recognizes microtubule polymerization status to screen for chemicals that interact with regulators of microtubule dynamics, we identified Pyr1, a cell permeable inhibitor of LIM kinase, which is the enzyme that phosphorylates and inactivates the actin-depolym...
for x>0. One says that 5-lim 5„ = 5|7?'-lim 5„ = 5] if lim^.,*, B(x; sk) = s[limx^x B'(x; sk)=s]. The relations between these Borel methods B, B', and their behavior under change of index are known [8, p. 183; 6; 7]. Following a suggestion of R. P. Boas, Jr., we intend to study in this paper the modified Borel methods which arise when the continuous variable x in (1.1) is replaced by the discre...
Let A be an alphabet of cardinality m, n k be a sequence of positive integers and ( ) n w A w k ∈ = . In this paper it is shown that if lim supn→ ∞ kn/ ln n < 1/ lnm then almost all words of length n over A contain the factor w, but if lim supn→ ∞ kn/ln n> 1/ lnm then this property is not true. Also, if lim infn→ ∞ kn/ lnn >1/ lnm then almost all words of length n over A do not contain the fact...
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