BACKGROUND The repolarizing cardiac rapid delayed rectifier current, I(Kr), is composed of ERG1 channels. It has been suggested that two isoforms of the ERG1 protein, ERG1a and ERG1b, both contribute to I(Kr). Marked heterogeneity in the kinetic properties of native I(Kr) has been described. We hypothesized that the heterogeneity of native I(Kr) can be reproduced by differential expression of E...

– It is shown that the gravitational redshift as predicted by Einstein’s theory is modified in the presence of a second-rank antisymmetric tensor (Kalb-Ramond) field in a string-inspired background spacetime. In the presence of extra dimensions, the RandallSundrum brane world scenario is found to play a crucial role in suppressing this additional shift. The bound on the value of the warp factor...

The isotopic abundance of (85)Kr in the atmosphere, currently at the level of 10(-11), has increased by orders of magnitude since the dawn of nuclear age. With a half-life of 10.76 years, (85)Kr is of great interest as tracers for environmental samples such as air, groundwater and ice. Atom Trap Trace Analysis (ATTA) is an emerging method for the analysis of rare krypton isotopes at isotopic ab...

Let Km −H be the graph obtained from Km by removing the edges set E(H) of the graphH (H is a subgraph ofKm). We use the symbol Z4 to denote K4−P2. A sequence S is potentially Km−H-graphical if it has a realization containing aKm−H as a subgraph. Let σ(Km−H,n) denote the smallest degree sum such that every n-term graphical sequence S with σ(S) ≥ σ(Km − H,n) is potentially Km − H-graphical. In th...

and K(s) = [ AK BK CK DK ] be an n κ order controller with transfer function K(s) = CK(sI − AK)−1BK + DK . We seek a reduced-order controller Kr(s) of order r with r nκ to replace K(s). Assume that both G(s) and K(s) are single-input single-output (SIS0), and that K(s) is a stable stabilizing controller. (The general case follows simply and will be presented in the full paper.) Requiring Kr(s) ...

• Objective: To compare rates of revision knee replacement (KR) surgery for patients who had 2 knees replaced simultaneously with rates for those who had staged surgery. • Design: Retrospective database study covering the period January 1985 through December 1990. • Participants: 11,771 Medicare recipients in the United States. • Main outcome measure: Rates of revision following primary bilater...

One way to describe a language’s grammar is as a compact system that encodes the regularities of the language. This system allows someone to immediately comprehend and generate novel linguistic items that follow those encoded regularities, and so grammars are often viewed as generative systems. Notably, because languages vary with respect to the specific regularities they have, the generative s...

The recessive mouse mutation kreisler affects hindbrain segmentation and inner ear development in homozygous mice. The mouse gene affected by the mutation was found to encode a basic domain leucine-zipper (bZIP)-type transcription factor of the Maf-family named kr (Cordes, S.P. and Barsh, G.S. (1994) Cell 79, 1025-1034). The avian bZIP transcription factor mafB, which shows high homology to kr,...