نتایج جستجو برای: مدل hlm
تعداد نتایج: 120705 فیلتر نتایج به سال:
Time-dependent inhibition (TDI) of the cytochrome P450 (P450) family of enzymes is usually studied in human liver microsomes (HLM) by investigating whether the inhibitory potency is increased with increased incubation times. The presented work was initiated after a discrepancy was observed for the TDI of an important P450 enzyme, CYP3A4, during early studies of the investigational drug compound...
To lower the possibility of late-stage failures in the drug development process, an up-front assessment of absorption, distribution, metabolism, elimination, and toxicity is commonly implemented through a battery of in silico and in vitro assays. As in vitro data is accumulated, in silico quantitative structure-activity relationship (QSAR) models can be trained and used to assess compounds even...
امروزه سازمان ها ساختار های جبران خدمات خود را تغییر داده، و نقش و جایگاه پرداخت مبتنی بر عملکرد در سبد پرداخت ها افزایش یافته است. پرداخت های عملکردی نیز در سطوح مختلف سازمان به طور مختلفی وجود دارد. تحقیقات مختلف نشان داده است در سازمان های با عملکرد بالا پرداخت مبتنی بر عملکرد نقش اصلی دارد. از طرفی، یکی دیگر از متغیرهای مهم در طراحی نظام جبران خدمات تعیین تفاوت یا پراکندگی پرداخت است. با به...
هدف این مطالعه بررسی روابط بین عملکرد خواندن و برخی متغیرهای سطح دانش آموز و معلم و بررسی درصد واریانس هر یک از سطوح در تبیین واریانس عملکرد خواندن است. بدین منظور، داده های پایه چهارم مطالعه پرلز 2006 ایران مورد استفاده قرار گرفت. تحلیل ما بر نمونه ایرانی شامل 5411 دانش آموز از 236 مدرسه تأکید دارد. متغیرهای بکار رفته در این تحلیل از دو سطح انتخاب شده اند: سطح دانش آموز (خودپنداره، نگرش) و سط...
Sulfadiazine hydroxylamine has been postulated to be the mediator of the greatly increased rates of adverse reactions to sulfadiazine experienced by people with human immunodeficiency virus infection. Therefore, we investigated the in vitro human cytochrome P450 (P450) and N-arylamine acetyltransferase (detoxification) metabolism of sulfadiazine. Formation of both the hydroxylamine and 4-hydrox...
Time-dependent inhibition (TDI) of the cytochrome P450 (P450) family of enzymes is usually studied in human liver microsomes (HLM) by investigating whether the inhibitory potency is increased with increased incubation times. The presented work was initiated after a discrepancy was observed for the TDI of an important P450 enzyme, CYP3A4, during early studies of the investigational drug compound...
Nicotine, the major addicting agent in tobacco and tobacco smoke, undergoes a complex metabolic pathway, with approximately 22% of nicotine urinary metabolites in the form of phase II N-glucuronidated compounds. Recent studies have shown that UGT2B10 is a major enzyme involved in the N-glucuronidation of several tobacco-specific nitrosamines. In the present study, microsomes of UGT2B10-overexpr...
Valproic acid (VPA) is a widely used anticonvulsant that is also approved for mood disorders, bipolar depression, and migraine. In vivo, valproate is metabolized oxidatively by cytochromes P450 and beta-oxidation, as well as conjugatively via glucuronidation. The acyl glucuronide conjugate (valproate-glucuronide or VPAG) is the major urinary metabolite (30-50% of the dose). It has been hypothes...
N-(2,4-dichlorophenyl)-5-methyl-1,2-oxazole-3-carboxamide (UTL-5g), a potential chemoand radioprotective agent, acts as a prodrug requiring bioactivation to the active metabolite 5-methylisoxazole-3carboxylic acid (ISOX). UTL-5g hydrolysis to ISOX and 2,4-dichloroaniline (DCA) has been identified in porcine and rabbit liver esterases. The purpose of this study was to provide insights on the met...
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