Author details Allied Health Research Unit, Southern Health, Cheltenham, VIC, 3192, Australia. Department of Physiotherapy, Monash University, Frankston, VIC, 3199, Australia. School of Podiatry, Charles Sturt University, Albury, NSW, 2460, Australia. School of Occupational Therapy, Charles Sturt University, Albury, NSW, 2460, Australia. Quantitative Consulting Unit , Charles Sturt University, ...

H. Jamali, S. J. Livesley, L. B. Hutley, B. Fest, and S. K. Arndt Landcare Research, Palmerston North 4410, New Zealand Department of Forest and Ecosystem Science, The University of Melbourne, VIC 3121, Australia Department of Geography and Resource Management, The University of Melbourne, VIC 3121, Australia Research Institute for the Environment and Livelihoods, Charles Darwin University, NT ...

Australian Archaeomagnetism Laboratory, Department of Archaeology, Environment and Community Planning, Faculty of Humanities and Social Sciences, La Trobe University, Melbourne Campus, Bundoora, VIC 3086, Australia Department of Anatomy and Developmental Biology, School of Biomedical Sciences, Faculty of Medicine, Nursing & Health Sciences, Monash University, Clayton, Melbourne, VIC 3800, Austr...

Health-related quality of life (HRQoL) is a broad concept reflecting a patient's general subjective perception of the effect of an illness or intervention on physical, psychological and social aspects of their daily life. HRQoL among patients infected with HIV has become an important indicator of impact of disease and treatment outcomes. A cross-sectional survey was carried out at Chitungwiza C...

MicroRNAs 21 and 145 exhibit inverse expression in Hepatocellular carcinoma (HCC), but how they relate to Smad3 C-terminal and Link region phosphorylation (pSmad3C and pSmad3L) downstream of TGF-β/MAPK signaling, remains inconclusive. Our results suggest microRNA-145 targets Smad3 in HepG2 cells. Decreased tumor volume and increased apoptosis were produced in both microRNA-21 antagomir and micr...

OBJECTIVE(S) Nowadays, cancer is an important public health problem in all countries. Limitations of current chemotherapy for neoplastic diseases such as severe adverse reactions and tumor resistance to the chemotherapeutic drugs have been led to a temptation for focusing on the discovery and development of new compounds with potential anticancer activity. MATERIALS AND METHODS A new series o...

The influence of comorbidities and worse physical status on mortality following total hip replacement (THR) leads to the idea that patient-reported health status may also be a predictor of mortality. The aim of this study was to investigate the relationship between patient-reported health status before THR and the risk of dying up to 5 years post-operatively. For these analyses, we used registe...

Cancer cells often gain advantage by reducing the tumor-suppressive activity of transforming growth factor-beta (TGF-beta) together with stimulation of its oncogenic activity as in Ras-transformed cells; however, molecular mechanisms remain largely unknown. TGF-beta activates both its type I receptor (TbetaRI) and c-Jun NH2-terminal kinase (JNK), which phosphorylate Smad2 and Smad3 at the COOH-...

OBJECTIVE To compare the performance of the recently developed Swedish experience-based time trade-off (TTO) valuation of the EuroQol-5D-3L (EQ-5D-3L) against the hypothetical-based TTO valuations from UK, US, Germany and Denmark. METHODS Type 2 diabetes patients from the Swedish National Diabetes Register (N = 1,757) responded to EQ-5D-3L questionnaire in 2008. Health utilities were compared...

Cancer cells often gain advantage by reducing the tumorsuppressive activity of transforming growth factor-B (TGF-B) together with stimulation of its oncogenic activity as in Ras-transformed cells; however, molecular mechanisms remain largely unknown. TGF-B activates both its type I receptor (TBRI) and c-Jun NH2-terminal kinase (JNK), which phosphorylate Smad2 and Smad3 at the COOH-terminal (pSm...