OBJECTIVE To test whether previously reported hip morphology or osteoarthritis (OA) susceptibility loci are associated with proximal femur shape as represented by statistical shape model (SSM) modes and as univariate or multivariate quantitative traits. METHODS We used pelvic radiographs and genotype data from 929 subjects with unilateral hip OA who had been recruited previously for the Arthr...

We demonstrate imaging of blood cells enclosed in chicken skin tissue using speckle scanning microscopy (SSM). Clear images of multiple cells were obtained with subcellular resolution and good image fidelity, provided that the object dimension was smaller than the maximum scanning range of the speckle pattern. These results point to the potential and the challenges of using SSM technique for bi...

Misquitta, Christine M., James Mwanjewe, Lin Nie, and Ashok K. Grover. Sarcoplasmic reticulum Ca2 pump mRNA stability in cardiac and smooth muscle: role of the 3 -untranslated region. Am J Physiol Cell Physiol 283: C560–C568, 2002. First published April 18, 2002; 10.1152/ ajpcell.00527.2001.—Stomach smooth muscle (SSM) and left ventricular muscle (LVM) express the sarco(endo)plasmic reticulum C...

Snowmelt onset in the upper Yukon River basin, Canada, can be derived from brightness temperatures (Tb) obtained by the Advanced Microwave Scanning Radiometer for EOS (AMSRE) on NASA’s Aqua satellite. This sensor, with a resolution of 14 x 8 km for the 36.5 GHz frequency and two to four observations per day, improves upon the twice-daily coverage and 37 x 28 km spatial resolution of the Special...

OBJECTIVES When analyzing shapes and shape variabilities, the first step is bringing those shapes into correspondence. This is a fundamental problem even when solved by manually determining exact correspondences such as landmarks. We developed a method to represent a mean shape and a variability model for a training data set based on probabilistic correspondence computed between the observation...

BACKGROUND More than 50 million people around the world are investigated for tuberculosis using sputum smear microscopy annually. This process requires repeated visits and patients often drop out. METHODS AND FINDINGS This clinical trial of adults with cough ≥2 wk duration (in Ethiopia, Nepal, Nigeria, and Yemen) compared the sensitivity/specificity of two sputum samples collected "on the spo...

Diabetic cardiomyopathy is the leading cause of heart failure among diabetic patients, and mitochondrial dysfunction has been implicated as an underlying cause in the pathogenesis. Cardiac mitochondria consist of two spatially, functionally, and morphologically distinct subpopulations, termed subsarcolemmal mitochondria (SSM) and interfibrillar mitochondria (IFM). SSM are situated beneath the p...

STUDY DESIGN Retrospective analysis of a prospective, multicenter cohort study. OBJECTIVE To estimate the added effect of surgical fusion as compared to decompression surgery alone in symptomatic lumbar spinal stenosis patients with spondylolisthesis. SUMMARY OF BACKGROUND DATA The optimal surgical management of lumbar spinal stenosis patients with spondylolisthesis remains controversial. ...

Cardiac ischemia decreases complex III activity, cytochrome c content, and respiration through cytochrome oxidase in subsarcolemmal mitochondria (SSM) and interfibrillar mitochondria (IFM). The reversible blockade of electron transport with amobarbital during ischemia protects mitochondrial respiration and decreases myocardial injury during reperfusion. These findings support that mitochondrial...

Cardiovascular complications, such as diabetic cardiomyopathy, account for the majority of deaths associated with diabetes mellitus. Mitochondria are particularly susceptible to the damaging effects of diabetes mellitus and have been implicated in the pathogenesis of diabetic cardiomyopathy. Cardiac mitochondria consist of two spatially distinct subpopulations, termed subsarcolemmal mitochondri...