Present studies determined the roles of the cyclooxygenase (COX) versus the lipoxygenase (LO) pathways in the metabolic pathway of arachidonic acid (AA) in the internal anal sphincter (IAS) tone. Studies were performed in the rat IAS versus the nontonic rectal smooth muscle (RSM). Indomethacin, the dual COX inhibitor, but not nordihydroguaiaretic acid (NDGA), the LO inhibitor, produced a precip...

Response surface methods (RSM) provide superb statistical tools for design and analysis of experiments aimed at process optimization. At the final stages of process development, RSM illuminates the sweet spot where high yield of in-specification products can be achieved at lowest possible cost. It produces statistically-validated predictive models and, with the aid of specialized software, resp...

This study aimed to investigate construct validity and factor structure of the Persian Occupational Self-Assessment (OSA; Baron, Kielhofner, Iyenger, Goldhammer, & Wolenski, 2003 ) based on the model of human occupation (MOHO). Three hundred and thirty-six (179 male and 157 female) Iranian junior high students were measured using the OSA. The data were analyzed using a Confirmatory Factor Analy...

CASPaxos is a replicated state machine (RSM) protocol, an extension of Synod. Unlike Raft and Multi-Paxos, it doesn’t use leader election and log replication, thus avoiding associated complexity. Its symmetric peer-to-peer approach achieves optimal commit latency in wide-area networks and doesn’t cause transient unavailability when any bN−1 2 c of N nodes crash. The lightweight nature of CASPax...

Response surface methodology (RSM) using a central composite design (CCD) was employed to optimize the conditions for extraction of antioxidants from black soybean (Glycine max var) sprouts. Three influencing factors: liquid-solid ratio, period of ultrasonic assisted extraction and extraction temperature were investigated in the ultrasonic aqueous extraction. Then Response Surface Methodology (...

A highly sensitive and selective high performance liquid chromatographic fluorescence detection method has been developed and validated for the quantification of rivastigmine in rat plasma and brain. Protein precipitation and one-step liquid-liquid extraction techniques were utilized for the extraction of RSM from brain and plasma, respectively, along with an internal standard. The chromatograp...

The preparation of nanocellulose via Cr(NO3)3-assisted sulfuric acid hydrolysis was optimized using response surface methodology (RSM). The experiment was performed using a five-level, four-factor central composite design coupled with RSM in order to optimize nanocellulose crystallinity and product yield. Four factors were evaluated for the preparation of nanocellulose: (1) reaction temperature...

Restricted and repetitive behaviors (RRBs) on the Autism Diagnostic Interview- Revised (ADI-R: Lord, Rutter, & Le Couteur (1994) were examined in 165 children with Autism Spectrum Disorders (ASD), 49 children with non-spectrum developmental disorders (DD), and 65 children with typical development (TD) at approximately 2 years of age. A factor analysis found evidence for a repetitive sensorimoto...