The growth and advantage of Building Information Modeling (BIM) has recently gained momentum in the expanding needs of the construction industry, one that varies across disciplines. The UK government is the largest public stakeholder client that has realized the benefits and advantages of BIM when used in procuring projects. The usage and adoption of BIM in all UK government-procured projects w...

Irs2-deficient mice develop type 2-like diabetes due to a reduction in β-cell mass and a failure of pancreatic islets to undergo compensatory hyperplasia in response to insulin resistance. In order to define the molecular mechanisms, we knocked down Irs2 gene expression in mouse MIN6 insulinoma cells. Insulin receptor substrate 2 (IRS2) suppression induced apoptotic cell death, which was associ...

Pyruvate kinase M2 (PKM2) contributes to the Warburg effect, a hallmark of cancer. We showed that PKM2 levels were correlated with overall survival (hazard ration = 1.675, 95% confidence interval: 1.389-2.019, P < 0.001) and disease-free survival (hazard ration = 1.573, 95% confidence interval: 1.214-2.038, P < 0.001) in a cohort of 490 patients with HCC. The correlations were further validated...

This paper presents a novel vision of paperless and visual lifecycle building management tools based on the coupling between Building Information Models (BIM) and Augmented Reality (AR) called Lifecycle Building Card. As the use of BIM increases within the architecture, engineering, and construction industries, new opportunities emerge to help stakeholders and maintenance operators to leverage ...

Productivity is a comprehensive problem in many countries. Particularly in construction and resources sectors, low productivity will potentially discourage future investments as building assets is becoming more and more unaffordable and unsustainable. In recent years, Building Information Modelling (BIM) is becoming much more active than ever. In order to fully realize where BIM is believed to ...

Facility Management (FM) is well known for its interdisciplinary knowledge and along with the growing number of green buildings and low-carbon buildings, the FM system become increasingly complex. Many practitioners consider Building Information Modeling (BIM) as the most important technology to bring about improvements. The purpose of this paper is to develop a BIM-enabled FM system which inte...

addiction is a phenomenon whereby suppression of a driver oncogene is associated with dramatic tumor regression that has been observed in experimental models and in response to targeted therapies [1]. However, the mechanism by which oncogene inactivation induces this massive reduction in tumor burden is not clear. In tumors addicted to the MYC oncogene, suppression of this oncogene leads to tum...

a r t i c l e i n f o Keywords: BIM GIS FM Integration Surface model BG-ETL In this study, we propose software architecture for the effective integration of building information modeling (BIM) into a geographic information system (GIS)-based facilities management (FM) system. This requires the acquisition of data from various sources followed by the transformation of these data into an appropri...