OBJECTIVE We previously identified a circulating autoantibody against a 43 kDa muscle autoantigen in sporadic inclusion body myositis (IBM) and demonstrated the feasibility of an IBM diagnostic blood test. Here, we sought to identify the molecular target of this IBM autoantibody, understand the relationship between IBM autoimmunity and muscle degeneration, and develop an IBM blood test with hig...

Inclusion body myositis (IBM) is an uncommon chronic inflammatory myopathy. Although the association between other myopathies and cancer has been well established, the relationship between IBM and neoplasia is not completely understood. Unlike polymyositis (PM) or dermatomyositis (DM), IBM rarely responds to immunosuppressive treatment and the response is seldom long-lasting. We describe a case...

The latest IBM zSeriest processor, the IBM System z10e processor, provides hardware support for the decimal floating-point (DFP) facility that was introduced on the IBM System z9t processor. The z9t processor implements the facility with a mixture of low-level software and hardware assists. Recently, the IBM POWER6e processor-based System pe 570 server introduced a hardware implementation of th...