background: although pentavalent antimony compounds are used as antileish-manial drugs but they are associated with limitations and several adverse complica-tions. therefore, always effort to find a new and effective treatment is desired. in this study, the effect of zno nanoparticles with mean particle size of 20 nanome-ters (nm) on leishmania major promastigotes and amastigotes was evaluated....

background: the aim of this study was to investigate the effects of leishmania major infection on the induction of oxidative stress in skin and lung of female mice. methods: balb/c mice were randomly divided into the control and experi-mental groups. the experimental groups were subcutaneously infected with in-oculums promastigotes of l. major . the animals were sacrificed at 20, 40, 60, 90 and...

background: the present study aimed to survey antileishmanial activity of methanolic holothuria leucospilota extract against leishmania major promastigotes in vitro. methods: promastigotes were cultured in rpmi 1640 and after reaching the stationary phase, the study was conducted with different concentrations of the extract. afterwards, mtt colorimetric assay for the obtaining of 50% inhibitory...

The hydroalcoholic extracts of dried ligulate florets of Calendula officinalis L., dried leaves of Plantago major L., and dried aerial parts of Vinca major L. were prepared and used as the main active ingredients of two types of anti-anorectal disease ointments and suppositories. Benzocaine was used in one of the formulations, while a mixture of belladonna dry extract and ephedrine sulfate ...

In Algeria, Leishmania infantum, Leishmania major, and Leishmania killicki (Leishmania tropica) are responsible for cutaneous leishmaniosis. We established a murine model of L. killicki infection to investigate its infective capacity, some immunophysiopathological aspects, and its suitability for pharmacological purposes. Following the injection of L. major or L. killicki metacyclic promastigot...

background: the rice weevil, sitophilus oryzae and rice moth, corcyra cephalonica are major and cosmopolitan insect. adults of s. oryzae (male and female) and both larvae are insatiable feeders on a great variety of grains. objective: this study was conducted to estimate the insecticidal effect of essential oils from peppermint, mentha piperita l. and black pepper, piper nigrum l. against two m...

BACKGROUND Historically, leishmanization is the most effective protective measure against Cutaneous Leishmaniasis (CL), CL lesion induced by leishmanization sometimes takes a long time to heal. Manipulation of leishmanization inoculums needed to induce a mild and acceptable CL lesion. The aim of this study was to explore if liposomal form of CpG ODN (Cytosin phosphate Guanin Oligodeoxynucleotid...

We used the RAPD-PCR method for distinguishing the main Old World Leishmania parasites Leishmania tropica, L. major, and L. infantum and applied it to Sauroleishmania species from Iran. Twelve out of 21 tested primers were suitable for identification of these parasites. The Jaccard similarity index was 0.30 for L. tropica and L. infantum as well as for L. major and L. infantum. The similarity c...