Muscle blood flow (MBF) was measured using the local (133)Xenon injection method in patients with Duchenne type muscular dystrophy (six), limb-girdle dystrophy (four), polymyositis (seven), and in normal controls (11). Measurements were made at rest and during hyperaemia induced by ischaemic exercise and by histamine injection. Capillary diffusion capacity was measured with the (51)Cr-EDTA meth...

Background Animal models are important to develop our understanding of the pathophysiology of cardiovascular disease and for the development of new therapies. While coronary autoregulation maintains resting myocardial blood flow (MBF) constant over a wide range of pathological conditions, MBF reserve during hyperaemic stress is impaired in several common disease processes. First pass contrast-e...

Chromatin modification through histone H3 lysine 36 methylation by the SETD2 tumor suppressor plays a key role in maintaining genome stability. Here, we describe a role for Set2-dependent H3K36 methylation in facilitating DNA replication and the transcriptional responses to both replication stress and DNA damage through promoting MluI cell-cycle box (MCB) binding factor (MBF)-complex-dependent ...

BACKGROUND The goal of this study was to examine a possible association between systemic microinflammation, as reflected by C-reactive protein (CRP) serum levels, and coronary vasomotion in patients with coronary risk factors but with angiographically normal coronary arteries. METHODS AND RESULTS Coronary vasomotor function was studied in response to cold pressor testing (CPT) in 71 patients ...

Background—We investigated the hemodynamic and coronary vasodilatory effects of CGS-21680, a potent selective adenosine A2A agonist, as well as its potential use as a new stress modality in combination with perfusion scintigraphy. Methods and Results—A stenosis of the left anterior descending coronary artery (LAD) was produced in dogs to reduce the reactive hyperemic response to ,20%. Adenosine...

The availability of plastic microspheres labeled with different -emitting isotopes has allowed the quantification of blood flow in different organs, including the heart (1). In the past 3 decades this has made it possible to study the changes in myocardial blood flow (MBF) under different physiologic and pathophysiologic conditions in experimental animals. In a similar fashion, the development ...

The transition from natural forest to plantations has increased dramatically in the past decades. Forest conversion will affect soil properties and thus ecosystem services. Based on indicators, we studied differences of services among three types Liuxihe National Park analyzed effects artificial results showed that carbon sequestration evergreen broadleaf (EBF) was stronger, organic density (36...

Mental stress testing has been proposed as a noninvasive tool to evaluate endothelium-dependent coronary vasomotion. In patients with coronary artery disease, mental stress can induce myocardial ischemia. However, even the determinants of the physiological myocardial blood flow (MBF) response to mental stress are poorly understood. Twenty-four individuals (12 males/12 females, mean age 49 +/- 1...

Since its original description 50 years ago, myocardial ischemia has been a recognized but underappreciated aspect of the pathophysiology of hypertrophic cardiomyopathy (HCM). Nevertheless, the assessment of myocardial ischemia is still not part of routine clinical diagnostic or management strategies. Morphologic abnormalities of the intramural coronary arterioles represent the primary morpholo...

The relationship between resting left ventricular (LV) myocardial blood flow (MBF) and hemodynamic determinants of myocardial oxygen consumption was investigated in 15 patients with multivessel coronary artery disease (CAD) and in 10 patients with normal coronary arteriograms. MeanLV MBF.per unit mass of tissue was measured with a multicrystal scintillation camera from the regional clearance ra...