Subclavian venous catheterization was previously frequently performed, but because of life-threatening complications such as hemothorax, pneumothorax, mediastinal hematoma, and myocardial injury, its use has become less common. However, this practice has some advantages in patient mobility, secured dressing, and rapidity and adequacy of vascular access. In some situations where patient comfort ...

BACKGROUND The human motor cortex (M1) has a role in motor learning. Antiepileptic drugs that suppress M1 excitability may affect learning, presumably by inhibiting long-term potentiation. Levetiracetam, a new antiepileptic drug with a unique preclinical profile, also suppresses M1 excitability, but in a way that is different from other antiepileptic drugs. The effect of levetiracetam on motor ...

The pinch-off of a two-dimensional region of inviscid fluid is investigated using numerical and analytical techniques. We find that pinch-off occurs when a sufficiently deformed 2D drop is released from rest. The asymptotic collapse of the pinching region is characterized by an anomalous, nonrational similarity exponent , indicating the existence of self-similarity of the second kind. Numerical...

The effects of mild stress on nonoxidative glucose metabolism were studied in the brain of the freely moving rat. Extracellular lactate levels in the hippocampus and striatum were monitored at 2.5-min intervals with microdialysis coupled with an enzyme-based flow injection analysis system. Ten minutes of restraint stress led to a 235% increase in extracellular lactate levels in the striatum. A ...

The mathematics of gauge theories lies behind many of the most profound advances in physics in the past 200 years, from Maxwell's theory of electromagnetism to Einstein's theory of general relativity. More recently it has become clear that gauge theories also emerge in condensed matter, a prime example being the spin-ice materials which host an emergent electromagnetic gauge field. In spin-ice,...

Seventeen patients with 28 flexor tendon injuries were examined after tendon repair. The current most frequently used evaluation systems, including grip and pinch strength, were compared with functional outcome as assessed by a questionnaire, evaluating Disabilities of Arm, Shoulder and Hand (DASH). Good correlation was found between Total Active Motion (TAM) and the Original Strickland test (k...

The pinch-off of an axisymmetric air bubble surrounded by an inviscid fluid is compared in four physical realizations: (i) cavity collapse in the wake of an impacting disk, (ii) gas bubbles injected through a small orifice, (iii) bubble rupture in a straining flow, and (iv) a bubble with an initially necked shape. Our boundary-integral simulations suggest that all systems eventually follow the ...

The heterotrimeric complex between integrin-linked kinase (ILK), PINCH, and parvin is an essential signaling platform, serving as a convergence point for integrin and growth-factor signaling and regulating cell adhesion, spreading, and migration. We report a 1.6-A crystal structure of the ILK ankyrin repeat domain bound to the PINCH1 LIM1 domain, revealing the molecular basis of ILK-PINCH inter...

The objective of this study was to determine the effects of grasp conditions (types of grasp, grasp width, glove and types of coupling) on maximal pushing force (MPF) and required pinch force (RPF) during snap fit assembly. The results indicated that the type of grasp, the type of coupling and wearing gloves have significant (p<0.05) effects on both MPF and RPF. Regarding the pair wise comparis...

BACKGROUND Several problems are associated with manual muscle testing and dynamometry in the hands of patients with Charcot-Marie-Tooth (CMT) disease. OBJECTIVE To evaluate the efficacy of the Rotterdam Intrinsic Hand Myometer (RIHM) to directly measure intrinsic hand muscle strength in CMT disease. METHODS We measured hand muscle strength and hand function in 41 patients with CMT disease. ...