PURPOSE To investigate a rationale of pancreatobiliary cancers, thymidylate synthase (TS) and dihydropyrimidine dehydrogenase (DPD) concentrations in cancer tissues were evaluated. PATIENTS AND METHODS Twenty-nine patients with pancreatic cancer (PC) and 43 with biliary tract cancer (BTC; 27 cases of bile duct cancer, 8 of gallbladder cancer and 8 of cancer of the papillary area) were include...

The thymidylate synthase (TS) gene is expressed at a much higher level in cells undergoing DNA replication than in nondividing cells. In growth-stimulated mammalian cells, TS mRNA content increases 10 to 20-fold as cells progress from G1 through S phase. However, the rate of transcription of the TS gene does not increase during this interval, indicating that the gene is regulated at the posttra...

Earlier studies showed that mice primed for a few hours with the trans-sialidase (TS) of Trypanosoma cruzi, the agent of Chagas' disease, become highly susceptible to trypanosomal infection. These studies suggest that TS affects parasite virulence independent of antigenic stimulation. Potentially, TS could enhance or reduce the virulence of heterologous microbes depending on the mechanism of TS...

Background Auto-immunization was proposed as the mechanism of contralateral testicular damage following unilateral vas deferens injuries. The objective of this experimental in vitro study was to elucidate the effect of tacrolimus (TS) as a powerful immunosuppressant on contralateral epididymal sperm fertilizing capacity following unilateral vas deferens obstruction (UVO) in mice. MaterialsAndMe...

During the Early-Middle Ordovician, Upper Yangtze Platform experienced extensive development of a distinctive set mixed siliciclastic-carbonate deposits known as Meitan Formation. To conduct comprehensive study relationship between sedimentation and sea-level changes, Hailong section, situated at southwest margin in SW China, was selected area due to its typical sedimentary sequence. This secti...

this study aims to design some dual-target anticancer candidates, capable to act as an alkylating agent as well as a thymidylate synthase (ts) inhibitor. the designed scaffold is a combination of nucleobase, amino acid and aziridine structures. the candidates are docked into ts and three dna double strand structures and evaluated based on their binding interaction energies and ligand efficienci...

Mainstream primary and secondary schools are increasingly committed to the inclusion of students with Tourette Syndrome (TS). This qualitative study explores teachers' perceptions factors that have contributed to, or hindered, their success in creating an inclusive environment for children Eight teachers (two males, six females) from mainstream United Kingdom (UK) took part semi-structured inte...

OBJECTIVES Preoperative low serum testosterone (TS) level has been reported to be associated with adverse pathologic results in patients with clinically localized prostate cancer (pCA) treated with radical prostatectomy (RP). However, prior studies failed to show prognostic impact of preoperative low TS in these patients. The aim of this study was to investigate the relationship between preoper...

Thymidylate synthase (TS) is an important target for cancer chemotherapy. However, several mechanisms of resistance to TS inhibitors have been described. One mechanism that may be relevant to short-term exposure to TS inhibitors occurs as a result of disruption of the autoregulatory loop, which allows TS to control its own translation. This disruption leads to up-regulation of TS protein and is...