Target Audience: MR researchers, basic and clinical scientists, radiologists Purpose: Bipolar disorder (BD) patients pass through a series of manic and depressive episodes. These episodes are associated with rapid mood changes, related to the functioning of the brain’s dopaminergic system. Dopamine is a neurotransmitter, which acts in the presence of iron as a neurotoxin due to the production o...

BACKGROUND Quantitative measures of 11C-raclopride receptor binding can be used as a correlate of postsynaptic D2 receptor density in the striatum, allowing 11C-raclopride positron emission tomography (PET) to be used for the differentiation of Parkinson's disease from atypical parkinsonian syndromes. Comparison with reference values is recommended to establish a reliable diagnosis. A PET templ...

We tested the hypothesis that methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism, folic acid deficiency and riboflavin deficiency, independently or interactively, are important determinants of genomic stability, cell death, cell proliferation and homocysteine (Hcy) concentration in 9-d human lymphocyte cultures. Lymphocytes of seven wild-type (CC) and seven mutant (TT) homozygotes w...

ABSTRACT Using a combined spectral and light-curve modelling approach, we fit massive energetic explosion model to the luminous Type Ib/IIb SN 2020cpg. This has an ejected mass of ∼(7 ± 2) M⊙ with final energy ∼(6 1) × 1051 erg MNi = 0.27 0.05 M⊙. The early spectra are hot blue weak He i lines, complicated Hα region suggested be multicomponent feature. Modelling required ∼0.08 H at velocities &...

We present the first actualistic study of rodents consumed by South American fox Lycalopex culpaeus smithersi (Achala culpeo fox), a subspecies that is endemic to highlands central Argentina. provide taphonomic characterization this canid based on digested micromammal bones, and compare it other carnivores. studied over 1000 bones derived from 83 scats collected in Quebrada del Condorito Nation...

Lowering the charge of Zintl anions by (element-)organic substituents allows their use as sources (semi)metal nanostructures in common organic solvents, realized for group 15 or Ge94− and Sn94−. We developed a new strategy other anions, using low-coordinate 3d metal complexes electrophiles. [K(crypt-222)]+ salts (TrBi3)2− dissolved situ Et2O and/or THF when reacted with [Mn(hmds)2]. Work-up aff...

Palm (Elaeis guineensis Jacquin) kernel cake protein (PKCP) was extracted and hydrolyzed using Alcalase® 2.4L to obtain hydrolysate (PKCPH), then fractionated size exclusion chromatography. PKCPH consisted of predominantly fraction one (PKCPH1), containing two peptides (4.9 kDa 6.3 kDa) with functional amide (6.75–7.04 ppm) amine (1.5–2.0 groups. PKCP shared similar amino acid profiles. PKCPH1 ...

This paper outlines how to conduct a simple meta-analysis of neuroimaging foci of activation in R. In particular, the first part of this paper reviews the nature of fMRI data, and presents a brief overview of the existing packages that can be used to analyze fMRI data in R. The second part illustrates how to handle fMRI data by showing how to visualize the results of different neuroimaging stud...

Introduction Different strategies have been proposed to create a template for fMRI brain image normalization, including the use population-based templates and individual subject templates. However the template selection of a certain study may depend on the population of the study, as well as the degree of spatial deformation allowed by the registration algorithm. In this study, we evaluated the...