IκB kinase/nuclear [corrected] factor κB (IKK/NF-κB) signaling exhibits important yet opposing functions in hepatocarcinogenesis. Mice lacking NEMO in liver parenchymal cells (LPC) spontaneously develop steatohepatitis and hepatocellular carcinoma (HCC) suggesting that NF-κB prevents liver disease and cancer. Here, we show that complete NF-κB inhibition by combined LPC-specific ablation of RelA...

The definition of a community in social networks varies with applications. To generalize different types of communities, the concept of linkpattern based community was proposed in a previous study to group nodes into communities, where the nodes in a community have similar intra-community and inter-community interaction behaviors. In this paper, by defining centroid of a community, a distance f...

A method for timbre-preserving pitch shifting of music signals based on estimating the order in linear predictive coding (LPC) is described. LPC is used for estimating a transfer function approximated using autoregressive (AR) models. We need to determine the appropriate number of poles in the AR model for LPC. For general audio signals, the number of poles varies with time because the number a...

Fourteen patients with high-risk T-lineage acute lymphoblastic leukemia (ALL) in complete remission underwent autologous bone marrow transplantation (BMT) in an attempt to eradicate their residual disease burden. A combined immunochemotherapy protocol using a cocktail of two immunotoxins directed against CD5/Tp67 and CD7/Tp41 T-lineage differentiation antigens in combination with the in vitro a...

Platelet-activating factor (PAF), protein kinase C (PKC)βI, transforming growth factor (TGF)‑β1 and aberrant extracellular matrix (ECM) deposition have been associated with diabetic nephropathy (DN). However, the mechanistic basis underlying this association remains to be elucidated. The present study investigated the association among the aforementioned factors in a DN model consisting of huma...

Lysophosphatidylcholine (LPC) accumulates in ischemic but not normal myocardium and has electrophyriological actions. We studied the effects of LPC on passive and active membrane properties and on repolarization in the Purkinje fibers of sheep using multiple microelectrodes: one for intracellular current injection and the other for transmembrane voltage (V_) recording. Synthetic 1palmitoyl LPC ...

Humans have a variety of characteristics that are different from one another. Characteristics possessed by humans genuine which can be used as differentiator between individual and another, is sound. Voice recognition called speech recognition. In this study, it was developed an voice system using combination the Linear Predictive Coding (LPC) method feature extraction K-Nearest Neighbor (K-NN)...

Location privacy protection in VANETs considers preserving two types of information: the locations and identifications of users. However, existing solutions which either replace identifications by pseudonyms or hide locations in areas cannot be directly applied to geographic routing protocols since they degrade network performance. To address this issue, we proposed a location-preserved content...