Metabolomic studies of increased fat oxidation showed increase in circulating acylcarnitines C2, C8, C10, and C12 and decrease in C3, C4, and C5. We hypothesize that urinary F2-isoprostanes reflect intensity of fatty acid oxidation and are associated with circulating C2, C8, C10, and C12 directly and with C3, C4, and C5 inversely. Four urinary F2-isoprostane isomers and serum acylcarnitines are...

This study describes the identification of Drosophila yellow-f and yellow-f2 as dopachrome-conversion enzymes responsible for catalysing the conversion of dopachrome into 5,6-dihydroxyindole in the melanization pathway. Drosophila yellow -y gene and yellow -b, -c, -f and -f2 genes were expressed in an insect cell/baculovirus expression system and their corresponding recombinant proteins were sc...

N-n-butyl haloperidol iodide (F2), a novel compound derived from haloperidol, protects against the damaging effects of ischemia/reperfusion (I/R) injury in vitro and in vivo. In this study, we hypothesized the myocardial protection of F2 on cardiomyocyte hypoxia/reoxygenation (H/R) injury is mediated by inhibiting autophagy in H9c2 cells. The degree of autophagy by treatment with F2 exposed to ...

In previous studies, we showed that the C-terminal domain, F2, but not the N-terminal domain, F1, is responsible for the binding of apolipoprotein [a] (apo[a]) to human fibronectin (Fn). To pursue those observations, we prepared, by both elastase digestion and recombinant technology, subsets of F2 of a different length containing either kringle (K) V or the protease domain (PD). We also studied...

Horowitz [Hor1] showed that for every n ≥ 2, there exist elements w1, . . . , wn in F2 = free(a, b) which generate non-conjugate maximal cyclic subgroups of F2 and which have the property that trace(ρ(w1)) = · · · = trace(ρ(wn)) for all faithful representations ρ of F2 into SL2(C). Randol [Ran] used this result to show that the length spectrum of a hyperbolic surface has unbounded multiplicity....

Crossbreeding between indigenous and exotic sheep breeds is the fastest method of increasing the performance of sheep in the tropics. The aim of this work was to assess the performance of Cameroon sheep (C) and their crossbreds (Cameroon x Mutton, F1) and (F2 from Cameroon x Milk sheep) under different housing and feeding conditions. The following traits were analysed: Pre-weaning performance d...

Changes in DNA methylation may play a role in the genetic mechanism underlying glucose intolerance in the offspring of mothers with diabetes. Here, we established a rat model of moderate intrauterine hyperglycemia induced by streptozotocin to detect glucose and lipid metabolism of first-generation (F1) and second-generation (F2) offspring. Moderate intrauterine hyperglycemia induced high body w...

Influenza A virus contains eight RNA segments and encodes 10 viral proteins. However, an 11th protein, called PB1-F2, was found in A/Puerto Rico/8/34 (H1N1). This novel protein is translated from an alternative open reading frame (ORF) in the PB1 gene. We analyzed the PB1 gene of 42 recent influenza A isolates in Taiwan, including 24 H1N1 and 18 H3N2 strains. One H1N1 isolate and 17 H3N2 isolat...

Let f1 (resp. f2) denote two (elliptic) newforms of prime level N , trivial character and weight 2 (resp. k + 2, where k ∈ {8, 12}). We provide evidence for the Bloch-Kato conjecture for the motive M = ρf1⊗ρf2 (−k/2−1) by proving that under some assumptions the p-valuation of the order of the Bloch-Kato Selmer group of M is bounded from below by the p-valuation of the relevant L-value (a specia...

This short note gives an alternative proof of the M-convex intersection theorem, which is one of the central results in discrete convex analysis. This note is intended to provide a direct simpler proof accessible to nonexperts. 1 M-Convex Intersection Theorem The M-convex intersection theorem [3, Theorem 8.17] reads as follows, where V is a nonempty finite set, and Z and R are the sets of integ...