Intestinal-type columnar epithelium in the (distal) oesophagus, known as Barrett’s oesophagus (BO), is a well-defined premalignant condition [32]. The risk for the development of oesophageal adenocarcinoma in a patient with BO is at least 30 times higher as compared to the general population [9]. Invasive cancer in BO, so called Barrett cancer, is preceded by stages of progressively severe dysp...

BACKGROUND AND OBJECTIVE Bronchiolitis obliterans (BO) has been reported to develop following ingestion of Sauropus androgynus (SA), a leafy shrub distributed in Southeast Asia. Little is known about direct effects of SA on airway resident cells or haematopoietic cells in vitro. Identification of the SA component responsible for the development of BO would be an important key to elucidate its m...

Closed-shell BO(2)(-) and BO(-) anions are proposed as high-efficiency luminescence centres in boron-nitrogen systems, which makes the anions localized and leads to a radiation transition.

Objective Mineral trioxide aggregate (MTA) cements contain two types of particles, namely Portland cement (PC) (nominally 80% w/w) and bismuth oxide (BO) (20%). This study aims to determine the particle size distribution (PSD) of PC and BO found in MTA. Materials and methods The PSDs of ProRoot MTA (MTA-P) and MTA Angelus (MTA-A) powder were determined using laser diffraction, and compared to s...

Alkylating agents are frequently used as first-line chemotherapeutics for various newly diagnosed cancers. Disruption of genome integrity by such agents can lead to cell lethality if DNA lesions are not removed. Several DNA repair mechanisms participate in the recovery of mono- or bi-functional DNA alkylation. Thus, DNA repair capacity is correlated with the therapeutic response. Here, we asses...

In many Reinforcement Learning (RL) domains there is a high cost for generating experience in order to evaluate an agent’s performance. An appealing approach to reducing the number of expensive evaluations is Bayesian Optimization (BO), which is a framework for global optimization of noisy and costly to evaluate functions. Prior work in a number of RL domains has demonstrated the effectiveness ...

BACKGROUND Upper gastrointestinal tract intestinal metaplasia (IM) is termed Barrett's oesophagus (BO) or gastric intestinal metaplasia (GIM), depending on its location. BO and GIM are associated with chemical exposure resulting from gastro-oesophageal reflux and chronic Helicobacter pylori infection, respectively. Paneth cells (PCs), characterised by cytoplasmic eosinophilic granules, are foun...

Inversion of atmospheric ducts is great importance in the field performance evaluation for radar and communication systems. Since model parameters machine learning play a crucial role prediction performance, this paper develops random forest (RF) integrated with Bayesian optimization (BO) called BO-RF duct prediction, BO adopted to determine appropriate during training process. In addition, K-f...