The Savitzky-Golay (SG) filter is widely used to smooth and differentiate time series, especially biomedical data. However, time series that exhibit abrupt departures from their typical trends, such as sharp waves or steps, which are of physiological interest, tend to be oversmoothed by the SG filter. Hence, the SG filter tends to systematically underestimate physiological parameters in certain...

The autosomal recessive mouse mutation "staggerer" (sg/sg), located on chromosome 9, has been recognized as a neurological mutant because of movement abnormalities and defective cerebellar development. We show here that the sg/sg mutation not only affects the development of the cerebellum, but also causes developmental and regulatory changes of the immune system: We observed, on gross inspectio...

The sense of hearing depends on the faithful transmission of sound information from the ear to the brain by spiral ganglion (SG) neurons. However, how SG neurons develop the connections and properties that underlie auditory processing is largely unknown. We catalogued gene expression in mouse SG neurons from embryonic day 12, when SG neurons first extend projections, up until postnatal day 15, ...

Background/Aims: The association between striae gravidarum (SG) and preterm delivery may be postulated because of sharing similar poor organization of extracellular matrix in both skin and cervix. Our goal was to compare the frequency of striae gravidarum in women who gave preterm birth and women who gave term birth. Methods: A case-control study was conducted in women who gave preterm birth (n...

Cucumber leaf spot virus (CLSV) is an aureusvirus (family Tombusviridae) that has a positive-sense RNA genome encoding five proteins. During infections, CLSV transcribes two subgenomic (sg) mRNAs and the larger of the two, sg mRNA1, encodes coat protein. Here, the viral RNA sequences and structures that regulate transcription and translation of CLSV sg mRNA1 were investigated. A medium-range RN...

OBJECTIVE To determine the value of sonography (SG) performed by the rheumatologist to diagnose carpal tunnel syndrome (CTS). METHODS Sixty-three patients with clinical signs of CTS according to the neurologist, based on patient history and clinical examination, were studied. In the 6 weeks prior to surgery, SG was performed by a rheumatologist and nerve conduction study (NCS) was assessed. I...

Low molecular sialoglycoconjugates were isolated by the charcoal adsorption method from the urines of patients with mucolipidosis (one patient with mucolipidosis type I variant and three patients with mucolipidosis type II). The sialoglycoconjugates were fractionated into two major fractions (SG-1 and SG-2) by Sephadex G-25 gel filtration, and a strikingly increased excretion of the SG-1 fracti...

The detection of double-stranded (ds) DNA by SYBR Green I (SG) is important in many molecular biology methods including gel electrophoresis, dsDNA quantification in solution and real-time PCR. Biophysical studies at defined dye/base pair ratios (dbprs) were used to determine the structure-property relationships that affect methods applying SG. These studies revealed the occurrence of intercalat...

The aim of this study was to examine the interaction of soybean-derived sterylglucoside (SG) with the human hepatoblastoma cell line HepG2 with regard to the penetration-enhancing effect of beta-sitosterol glucoside (Sit-G) to clarify the accumulation of SG-containing liposomes (SG-liposomes) to the liver in vivo. The approach was based on measurement of the association of SG-liposomes labeled ...

The sine-Gordon (SG) equation and perturbed nonlinear Schrödinger (NLS) equations are studied numerically for modeling the propagation of two space dimensional (2D) localized pulses (the so-called light bullets) in nonlinear dispersive optical media. We begin with the (2 + 1) SG equation obtained as an asymptotic reduction in the two level dissipationless Maxwell–Bloch system, followed by the r...