Folding catalysts of the endoplasmic reticulum (ER), such as protein disulfide isomerase (PDI), accelerate the slow chemical steps, such as disulfide bond formation, that accompany protein folding. Molecular chaperones of the ER, notably the heavy chain-binding protein, BiP (grp78), bind and release unfolded proteins in an ATP-dependent fashion. In vitro, the fate of reduced, denatured lysozyme...

The purpose of this study was to determine the optimum pressure support (PS) in six patients with respiratory failure. Esophageal pressure (Pe), gastric pressure (Pg), airway pressure, and transdiaphragmatic pressure (Pdi), obtained by subtracting Pe from Pg, were measured using a newly developed multiluminal nasogastric catheter. For each patient, different PS levels were selected every 20 min...

The microsomal triglyceride transfer protein (MTP) complexed to protein disulphide isomerase (PDI) is obligatory for the assembly of chylomicrons and very-low-density lipoproteins. The determination of the atomic structure of the MTP-PDI heterodimer has important implications for the treatment of those forms of hyperlipidaemia associated with the overproduction of very-low-density lipoproteins,...

PURPOSE The purpose of this study was to determine whether the outer nuclear layer (ONL) deformation detected by spectral-domain optical coherence tomography (SD-OCT) is correlated with visual acuity before and after surgery in patients with idiopathic epiretinal membrane (ERM). METHODS Forty-four eyes of 44 patients who underwent vitreous surgery for treatment of ERM were included. All patie...

A novel ion-mediated self-assembly method was applied for integration of graphene oxide (GO), propanoic- and glutaric-substituted perylenes (glu-PDI PA-PDI), Zn (OAc)2 into new hybrid materials with photocatalytic properties. The structuring chromophores through coordination bonding on the GO surface is controlled by chemistry PDI linkers. Four-substituted glu-PDI forms consolidated microporous...

Irrigated agriculture in semi-arid regions is expected to increase the future, which puts greater demands on scarce water resources. Sustainable irrigation strategies will support agricultural resilience climatic change. The response of “Sweetheart”/Mazzard sweet cherry trees ( Prunus avium L.) postharvest deficit (PDI), as a conservation method, was studied over three seasons (2019–2022) Okana...