نتایج جستجو برای: شاخص moa
تعداد نتایج: 78987 فیلتر نتایج به سال:
This paper describes the construction and enumeration of mixed orthogonal arrays (MOA) to produce optimal experimental designs. A MOA is a multiset whose rows are the different combinations of factor levels, discrete values of the variable under study, having very well defined features such as symmetry and strength three (all main interactions are taken in consideration). The applied methodolog...
Omacetaxine mepesuccinate was originally identified more than 35 years ago and initial studies in chronic myeloid leukemia (CML) showed promising activity. It has also been studied in other hematologic and solid tumors as both a single agent and in combination with other treatments. However, the introduction of imatinib and related tyrosine kinase inhibitors (TKIs) abated the clinical developme...
We report the first unambiguous detection and mass measurement of an isolated stellar-mass black hole (BH). used Hubble Space Telescope (HST) to carry out precise astrometry source star long-duration (t_E~270 days), high-magnification microlensing event MOA-2011-BLG-191/OGLE-2011-BLG-0462 (hereafter designated as MOA-11-191/OGLE-11-462), in direction Galactic bulge. HST imaging, conducted at ei...
One of the most startling discoveries in avian molecular phylogenetics is that the volant tinamous are embedded in the flightless ratites, but this topology remains controversial because recent morphological phylogenies place tinamous as the closest relative of a monophyletic ratite clade. Here, we integrate new phylogenomic sequences from 1,448 nuclear DNA loci totaling almost 1 million bp fro...
We present a framework for active learning on evolving data streams, as an extension to the MOA system. In learning to classify streaming data, obtaining the true labels may require major effort and may incur excessive cost. Active learning focuses on learning an accurate model with as few labels as possible. Streaming data poses additional challenges for active learning, since the data distrib...
This paper presents a new experimental framework for studying multi-label evolving stream classification, with efficient methods that combine the best practices in streaming scenarios with the best practices in multi-label classification. Many real world problems involve data which can be considered as multi-label data streams. Efficient methods exist for multi-label classification in non strea...
Changes in cellular gene expression in response to small-molecule or genetic perturbations have yielded signatures that can connect unknown mechanisms of action (MoA) to ones previously established. We hypothesized that differential basal gene expression could be correlated with patterns of small-molecule sensitivity across many cell lines to illuminate the actions of compounds whose MoA are un...
Real-time classification of massive email data is a challenging task that presents its own particular difficulties. Since email data presents an important temporal component, several problems arise: emails arrive continuously, and the criteria used to classify those emails can change, so the learning algorithms have to be able to deal with concept drift. Our problem is more general than spam de...
In this work we consider the efficient computation of inner and outer products of arbitrary multi-dimensional arrays (tensors). Our algorithm was presented in a previous work and was derived and expressed using the formalism known as A Mathematics of Arrays (MoA) [1]. The routine maximizes data locality and computes both operations (inner and outer product) in a single piece of code. In this wo...
Following its validation and wide application in rheumatoid arthritis (RA), synovial tissue analysis has recently been applied to studies on Psoriatic Arthritis (PsA). Such studies aim to thereby clarify its distinctive features and the nature of specific responses upon administration of disease modifying anti-rheumatic drug (DMARD) or biologic agents. In consequence, insights to disease pathog...
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