Dimethyl fumarate (DMF) is an effective treatment option for relapsing-remitting multiple sclerosis (MS), but its therapeutic mechanism of action has not been fully elucidated. A better understanding of its mechanism will allow for the development of assays to monitor its clinical efficacy and safety in patients, as well as guide the development of the next generation of therapies for MS. In or...

The synthesis of several phosphine Cu(I) complexes is reported, and their reactivity towards the solvents ethylenediamine (en) and dimethylformamide (dmf) has been investigated. CuX(PPh3) [X = Cl (1), Br (2)], CuCl(PCy3) (3) and CuCl(PPr3)n [n = 1 (4), 2 (5)] were prepared according to adapted literature procedures. The complexes CuCl(PPr3)n were obtained in crystalline form from a hexane solut...

Cationic and mixed-valent forms of Fe3O(CO2)6 trigonal prismatic clusters have been linked by ditopic links, namely, 1,4-benzenedicarboxylate (1,4-BDC) and 1,3-benzenedicarboxylate (1,3-BDC), to produce two 3-periodic metal-organic frameworks (MOFs), [Fe3O(1,4-BDC)3 (DMF)3][FeCl4] x (DMF)3 (MOF-235) and Fe3O(1,3-BDC)3 (py)3 x (py)0.5(H2O)1.5 (MOF-236) (DMF = N,N-dimethylformamide, py = pyridine...

The asymmetric unit of the title complex, [Co(DMF)(6)](ClO(4))(2) (DMF = N,N-dimethyl-formamide, C(3)H(7)NO), consists of two half complex cations with the Co(2+) metal ions located on centers of inversion and two perchlorate anions. In the crystal packing, each Co(2+) ion is coordinated by six mol-ecules of DMF in a slightly distorted octa-hedral geometry. The crystal structure is mainly stabi...

The structures of micelles of the surfactant polysorbate 80 (Tween 80) in 0-50% aqueous N,N-dimethylformamide (DMF) solutions (pH 7.2, ionic strength 2.44 mM) were investigated by means of small-angle X-ray scattering. At all the tested DMF concentrations, core-shell cylinder micelles formed; that is, increasing the concentration of DMF did not result in changes in the shape of the micelles. Th...

This paper presents a low-power structure of digital matched filters (DMFs), which is proposed for direct sequence spread spectrum systems. Traditionally, low-power approaches for DMFs are based on either the transposedform structure or the direct-form one. A new hybrid structure that employs the direct-form structure for local addition and the transposed-form structure for global addition is u...

We examine the completeness of death reporting in the Social Security Administration's Death Master File (DMF) through comparison with deaths by year and age group reported in official U.S. vital statistics. For most years since 1973, results suggest that the DMF includes 93 percent to 96 percent of deaths of individuals aged 65 or older. Although studies have shown that the National Center for...

Digital microfluidics (DMF) is an emerging liquid-handling technology that enables individual control over droplets on an open array of electrodes. These picoliter- to microliter-sized droplets, each serving as an isolated vessel for chemical processes, can be made to move, merge, split, and dispense from reservoirs. Because of its unique advantages, including simple instrumentation, flexible d...

Does Nrf2 help nerves to survive? Dimethyl fumarate (DMF) has recently been approved for the treatment of relapsing-remitting multiple sclerosis (RRMS) after showing beneficial effects on clinical and radiologic endpoints in 2 phase 3 clinical trials. 1,2 While DMF's mode of action is not completely understood, experimental data suggest that putative neuroprotective properties may be mediated b...

The key steps in oligosaccharide synthesis are protectinggroup manipulation and stereoselective glycosylation. Various strategies have emerged to expedite glycosylation, and some of these strategies have been elaborated for automated solid-phase synthesis and one-pot cascade glycosylation. Most glycosylation strategies rely on traditional methods for stereochemical control over glycosidic-bond ...