نتایج جستجو برای: شاخص cpt

تعداد نتایج: 79993  

2002
Eric K. Rowinsky Jinee Rizzo Leonel Ochoa Chris H. Takimoto Bahram Forouzesh Garry Schwartz Lisa A. Hammond Amita Patnaik Joseph Kwiatek Andrew Goetz Louis Denis Jeffrey McGuire Anthony W. Tolcher

Purpose: To assess the feasibility of administering camptothecin (CPT), the prototypic topoisomerase I inhibitor, as polyethylene glycol (PEG)-CPT, a macromolecule consisting of CPT conjugated to chemically modified PEG. The study also sought to determine the maximum-tolerated dose (MTD) of PEG-CPT, characterize its pharmacokinetic behavior, and seek preliminary evidence of anticancer activity....

Journal: :Cancer research 2000
S Cao Y M Rustum

The basis for current clinical trials in the treatment of colorectal cancer with the combination of irinotecan (CPT-11) and 5-fluorouracil (FUra) with or without leucovorin (LV) is their proven activity as single agents, their different mechanisms of action, and lack of CPT-11 cross-resistance to previous FUra/LV treatment. The role of drug dose and administration sequence in this combination w...

2002
Shin-Young Park Wing Lam Yung-chi Cheng

X-ray repair cross-complementing gene I protein (XRCC1) in complex with DNA polymerase , DNA ligase III, and poly(ADP-ribose) polymerase is important in the base excision repair process. Previously, we isolated camptothecin (CPT)-resistant cell lines (KB100 and KB300) from the human epidermoid carcinoma cell line KB by exposure to CPT. From these CPT-resistant cell lines, their revertants (KB10...

2008
V. Alan Kostelecký

Possible signals for indirect CPT violation arising in experiments with neutral kaons are considered in the context of a general CPTand Lorentz-violating standard-model extension. Certain CPT observables can depend on the meson momentum and exhibit sidereal variations in time. Any leading-order CPT violation would be controlled by four parameters that can be separately constrained in appropriat...

Journal: :Journal of applied physiology 1998
P M Berthon R A Howlett G J Heigenhauser L L Spriet

This study was designed to compare the activity of skeletal muscle carnitine palmitoyltransferase I (CPT I) in trained and inactive men (n = 14) and women (n = 12). CPT I activity was measured in intact mitochondria, isolated from needle biopsy vastus lateralis muscle samples ( approximately 60 mg). The variability of CPT I activity determined on two biopsy samples from the same leg on the same...

Journal: :Cancer research 1996
L P Rivory J F Riou M C Haaz S Sable M Vuilhorgne A Commerçon S M Pond J Robert

Irinotecan [7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (CPT-11)] is a promising water-soluble analogue of camptothecin [S. Sawada et al., Chem. & Pharm. Bull. (Tokyo), 39: 1446-1454, 1991]. We have reported previously the presence of an important polar metabolite, in addition to 7-ethyl-10-hydroxycamptothecin (SN-38) beta-glucuronide, in samples of plasma taken from patie...

Journal: :Cancer research 1987
T Kunimoto K Nitta T Tanaka N Uehara H Baba M Takeuchi T Yokokura S Sawada T Miyasaka M Mutai

The search for new water-soluble analogues of camptothecin (CPT) with higher activity and less toxicity has led to the development of a novel compound, 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxy-camptothecin (CPT-11), which showed significant antitumor activity against a broad spectrum of experimental tumor models by i.p., i.v., or oral administration. When its activity against L1210...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 1997
L P Rivory M C Haaz P Canal F Lokiec J P Armand J Robert

Irinotecan (CPT-11) is an analogue of 20(S)-camptothecin with promising activity against several tumor types. In patients, CPT-11 is metabolized to 7-ethyl-10-hydroxycamptothecin (SN-38) and to the beta-glucuronide of SN-38. Recently, we identified an additional metabolite of CPT-11, 7-ethyl-10-[4-N-(5-aminopentanoic acid)-1-piperidino] carbonyloxycamptothecin (APC; L. P. Rivory et al. , Cancer...

Journal: :Anticancer research 2011
M Czejka A Kiss C Koessner R Terkola D Ettlinger J Schueller

Biotransformation of irinotecan (CPT-11) into its pharmacologic active metabolite SN-38 was investigated in patients treated for advanced colorectal cancer. A dose of 180 mg/m(2) CPT-11 was administered to 6 patients by 60 min hepatic intra-arterial infusion (HAI) via a surgically implanted Port-a-Cath® system. Blood samples were collected from 0 to 360 min after start of HAI, and CPT-11 plus m...

Journal: :The Journal of biological chemistry 2014
Yoshifumi Hosono Takuya Abe Masato Higuchi Kosa Kajii Shuichi Sakuraba Shusuke Tada Takemi Enomoto Masayuki Seki

The replication fork temporarily stalls when encountering an obstacle on the DNA, and replication resumes after the barrier is removed. Simultaneously, activation of the replication checkpoint delays the progression of S phase and inhibits late origin firing. Camptothecin (CPT), a topoisomerase I (Top1) inhibitor, acts as a DNA replication barrier by inducing the covalent retention of Top1 on D...

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