INTRODUCTION Receptor activator of nuclear factor kappa B ligand (RANKL) is a key regulator of bone metabolism. Anti-citrullinated protein antibodies (ACPA) have been suggested to cause bone destruction by osteoclast activation. We investigated the relationship between RANKL and ACPA in patients with early untreated rheumatoid arthritis (RA). METHODS Patients with newly diagnosed untreated RA...

1 CITEC, Bielefeld University, Germany [email protected] [email protected] [email protected] 2 Alexandru Ioan Cuza University of Iasi, Romania [email protected] 3 IBM Research, Dublin, Ireland [email protected] 4 AKSW, University of Leipzig, Germany [email protected] 5 INRIA Sophia-Antipolis Méditerrané, Cedex, France elena.cabrio@i...

Physiological responses in the Concealed Information Test (CIT) are known to depend on the depth of encoding critical items; CIT questions commonly refer to knowledge about critical items. It is unclear to what extent (1) different modes of item handling in a mock-crime, and (2) alternative questioning formats, e.g. asking about participants’ particular actions with the critical items, influenc...

Biological functions of proteins are influenced by posttranslational modifications such as on/off switching by phosphorylation and modulation by glycosylation. Proteolytic processing regulates cytokine and chemokine activities. In this study, we report that natural posttranslational citrullination or deimination alters the biological activities of the neutrophil chemoattractant and angiogenic c...

Following the idea that response inhibition processes play a central role in concealing information, the present study investigated the influence of a Go/No-go task as an interfering mental activity, performed parallel to the Concealed Information Test (CIT), on the detectability of concealed information. 40 undergraduate students participated in a mock-crime experiment and simultaneously perfo...

BACKGROUND Allergen immunotherapy (AIT) is currently the only immune-modifying treatment for allergic disease. The clinical efficacy of AIT for the treatment of allergic rhinitis and bronchial asthma is well documented. However, many factors including inconvenience, cost, side effects, and adherence influence the initiation and persistence of AIT, and patients lack knowledge and have misconcept...

BACKGROUND The purpose of this study was to explore the experiences of cancer patients' utilising complementary and integrative therapies (CIT) within integrative oncology centres across Western Australia. METHODS Across four locations 135 patients accessed CIT services whilst undergoing outpatient medical treatment for cancer. Of the 135 patients, 66 (61±12 y; female n=45; male n=21) agreed ...

Hyperechogenic signal of substantia nigra (SN) in transcranial sonography (TCS) and reduced striatal uptake in FP-CIT SPECT are common findings in idiopathic Parkinson's disease (PD). But so far it is unknown whether the extent of SN hyperechogenicity represents a correlate for the degeneration of presynaptic dopaminergic neurons in PD. We performed TCS and 123I-labelled N-(3-fluoropropyl)-2ss-...

Citalopram (CIT), 1-(3-dimethylaminopropyl)-1-(4-fluorophenyl)-5-phthalancarbonitrile, a selective serotonin reuptake inhibitor, is one of the most widely used antidepressants for the treatment of anxiety, obsessional, and control disorders. The degradation of the pharmaceutical CIT hydrogen bromide in water was investigated in the dark and in a growth chamber outfitted with fluorescent lamps s...

1. On a case of pericardial effusion, in which paracentesis was performed Practitioner, 1873, 11, 265-270. 2. Aneurysm at base of left ventricle of heart Trans. Path. Soc. Lond., 1875, 26, 65-6. 3. Case of acute tuberculosis in a child aged four months Brit. med. J., 1876, 2, 552. 4. Congenital heart disease; two cases Trans. path. Soc. Lond., 1876, 27, 140-2. 5. On a case of tubercle of the pa...