In the nanomolar enzyme and inhibitor concentration range, 1 mol of mucus proteinase inhibitor (MPI) inhibits 1 mol of neutrophil elastase, cathepsin G, trypsin, and chymotrypsin. In the micromolar concentration range, the enzyme:inhibitor binding stoichiometry is still 1:1 for elastase but shifts to 2:1 for the three other proteinases. These data could be confirmed by three nonenzymatic method...

Background False positive nuclear stress myocardial perfusion imaging(MPI) findings are known to occur in obese patients and women with large breasts due to attenuation artifact. A false positive MPI study may lead to unnecessary coronary arteriography(Cath). CMR stress perfusion imaging is not affected by obesity and has better spatial resolution than MPI, without radiation exposure. The CE-MA...

Multi-threaded performance in MPI is of concern for future systems, particularly at Exascale, where massive concurrency will be necessary to leverage the full power of systems. While MPI provides generalized solutions and additional proposals like endpoints expand this general model, examining common use cases that have good solutions that may not be universally applicable is a viable additiona...

This paper describes the implementation, usage and experience with the MPI performance revealing extension interface (Peruse) into the Open MPI implementation. While the PMPI-interface allows timing MPI-functions through wrappers, it can not provide MPI-internal information on MPI-states and lower-level network performance. We introduce the general design criteria of the interface implementatio...

This paper proposes an interface that will allow MPI 2 dynamic programs – those using MPI SPAWN, CONNECT/ACCEPT, or JOIN – to provide information to parallel debuggers such as TotalView about the set of processes that constitute an individual application. The TotalView parallel debugger currently obtains information about the identity of processes directly from the MPI library using a widely ac...

The Message Passing Interface (MPI) is designed as an architecture independent interface for parallel programming in the shared-nothing, message passing paradigm. We briefly summarize basic requirements to a high-quality implementation of MPI for efficient programming of SMP clusters and related architectures, and discuss possible, mild extensions of the topology functionality of MPI, which, wh...

The rodent model of myocardial infarction (MI) is extensively used in heart failure studies. However, long-term follow-up of echocardiographic left ventricular (LV) function parameters such as the myocardial performance index (MPI) and its ratio with the fractional shortening (LVFS/MPI) has not been validated in conjunction with invasive indexes, such as those derived from the conductance cathe...

Individuals with congenital disorders of glycosylation (CDG) have recessive mutations in genes required for protein N-glycosylation, resulting in multi-systemic disease. Despite the well-characterized biochemical consequences in these individuals, the underlying cellular defects that contribute to CDG are not well understood. Synthesis of the lipid-linked oligosaccharide (LLO), which serves as ...

A new fuel quality indicator called micropyrolysis index (MPI) is proposed for quantifying sooting tendencies of fuels in research laboratories. The MPI has been designed with the following characteristics: (i) oxygen independence, since sooting tendencies can change dramatically with varying oxygen concentration, (ii) reduced sample volume that can be utilized on a laboratory scale, (iii) impr...