AIM To evaluate the pharmacodynamics of lixisenatide once daily vs sitagliptin once daily in Japanese patients with type 2 diabetes receiving insulin glargine U100. MATERIALS AND METHODS This multicentre, open-label, phase IV study (NEXTAGE Study; ClinicalTrials.gov number, NCT02200991) randomly assigned 136 patients to either lixisenatide once daily via subcutaneous injection (10 µg initiall...

The finding that liver necrosis caused by the environmental glutathione (GSH)-depleting chemical, bromobenzene (BB) is associated with marked impairment in O- and S-methylation of BB metabolites in Syrian hamsters raises questions concerning the role of methyl deficiency in BB toxicity. N-Acetylmethionine (NAM) has proven to be an effective antidote against BB toxicity when given after liver GS...

In this work, a model to estimate systolic blood pressure (SBP) using photoplethysmography (PPG) and electrocardiography (ECG) is proposed. Data from 19 subjects doing a 40 min exercise was analyzed. Reference SBP was measured at the finger based on the volume-clamp principle. PPG signals were measured at the finger and forehead. After an initialization process for each subject at rest, the mod...

OBJECTIVE To evaluate whether fat quality, in the context of meals with high- (HGI) or low-glycemic index (LGI), influences postprandial blood glucose (PPG) response in patients with type 1 diabetes. RESEARCH DESIGN AND METHODS According to a randomized crossover design, 13 patients with type 1 diabetes on insulin pump consumed two series (HGI or LGI) of meals with the same carbohydrate quant...

In this paper a simple method for determining the physiological parameters of the face of different subjects using basic Logitech webcam was introduced. The physiological pulse waves were extracted from imaging PPG systems. The IR light is focussed on the non-contact surface whose influence gives a relationship between ambient light intensity and the normalised PPG Signals. This provides the pu...

This paper presents the recommendation techniques applied in Personal Program Guide (PPG), a system generating personalized Electronic Program Guides for digital TV. The PPG recommends TV programs by relying on the integration of heterogeneous user modeling techniques. Copyright Springer Verlag. This paper is going to appear in the Proceedings of the 8th AI*IA Conference, Pisa, 2003, published ...

Wearable physiological monitoring systems have gained popularity in the recent years due to their ability to continuously monitor physiological signals, thereby making them suitable for home-healthcare applications. The electrocardiogram (ECG), phonocardiogram (PCG) and photoplethysmogram (PPG) signals have been studied and it has been observed that there is a correlation between the three sign...