objective: the possible toxicity of drugs in pregnancy should be tested before their use in pregnant patients. in the present study, we aimed to evaluate the safety of phytovagex, a pessary formulation of nigella sativa (n. sativa), which is already in clinical use for vaginal fungal infection. materials and methods: the pregnant rats were treated intravaginal with physiological saline (vehicle...

objective(s):the use of doxorubicin (dox) is limited by its dose-dependent cardio toxicity in which reactive oxygen species (ros) play an important role in the pathological process. the aim of this study was to evaluate the protective effect of three medicinal plants, nigella sativa (n), glycyrrhiza glabra (g) and zingiber officinale (z), and their combination (ngz), against dox-induced apoptos...

objective(s): there are several scolicidal agents for inactivation of hydatid cyst protoscolices during surgery, but most of them are associated with adverse side effects such as sclerosing cholangitis and liver necrosis. the present study was aimed to evaluate scolicidal effects of various extracts of nigella sativa seeds againstprotoscoleces of hydatid cyst in an in vitro model. materials and...

introduction: hyperalgesia is considered as one the marked signs of subchronic diabetes mellitus that could affect the life style of patients. considering the evidence on the antidiabetic and analgesic effects of nigella sativa (ns), this study was designed to investigate the analgesic effects of ns on formalin-induced nociceptive responses (standard formalin test) in streptozotocin (stz)-induc...

objective: the clinical use of cisplatin is highly restricted, because of its nephrotoxicity.in this study the protective effect of nigella sativa (n. sativa) against cisplatin-induced nephrotoxicity was investigated in rats. materials and methods: in the current study, the effects of the administration of aqueous-ethanolic extract of n. sativa (100 and 200 mg/kg, bw) and vitamin e (100 mg/kg, ...

Methadone is widely being used for opioid substitution therapy. However, the administration of methadone to opioid dependent individual is frequently accompanied by withdrawal syndrome and chemical dependency develops. Other than that, it is also difficult to retain patients in the treatment programme making their retention rates are decreasing over time. This article is written to higlights th...

This survey was undertaken in the Errachidia province in south-eastern Morocco in order to inventory the main medicinal plants used in folk medicine to treat arterial hypertension and diabetes mellitus. Four hundred individuals who knew about and/or had used the medicinal plants for the indicated diseases, including some herbal healers, were interviewed throughout different regions of the provi...