In spite of significant advances in the understanding of molecular processes in tumor biology that have led to the development of oncologic therapeutic strategies, the prognosis for several types of tumors (such as brain, pancreas, or hepatic malignancies) remains dismal. Without question, a strong need exists for continued investigations in new agents and new therapeutic regimens. The realizat...

Cancer is the leading cause of disease-related death in companion animals such as dogs and cats. Despite recent progress in the diagnosis and treatment of advanced canine and feline cancer, overall patient treatment outcome has not been substantially improved. Virotherapy using oncolytic viruses is one promising new strategy for cancer therapy. Oncolytic viruses (OVs) preferentially infect and ...

The Optical Vortex Interferometer (OVI) is described in earlier paper as usefully tool to generate regular lattice of optical vortices (OVs) by interference of three plane wave. To practically use OVI in metrology method to localization of vortex points (VPs) is necessary. In this paper method with phase shift technique to VPs localisation is presented. Phase shift technique in this method is a...

A number of arguments are given against the traditional word order typology based on the six types SOY, SVO, VSO, VOS, OVS, and OSV, and in favour of an alternative typology based on two binary parameters OV vs. VO and SV vs. VS. The arguments given include ones based on various advantages of collapsing VSO and VOS into a single type, the infrequency of clauses containing a noun subject and nou...

The performance of the official Veterinary Services is determined by a number of factors, including, among others, the interaction of three different but complementary types of knowledge: (A) biological and veterinary science (including epidemiology); (B) organisational knowledge; and (C) economic knowledge. This paper argues that knowledge types (B) and (C) will be of increasing importance in ...

The challenges of voltage decay and irreversible oxygen release for lithium-rich layered oxide cathode materials have hindered their commercial application despite high energy density low cost. Herein, a facile post-annealing strategy is developed to pre-introduce vacancies (OVs) into Li1.2Mn0.457Ni0.229Co0.114O2 materials. induced OVs modify the local Mn coordination environments, enhance stru...

Abstract Aim Single-voxel spectroscopy (SVS) discriminates amongst brain tumours by measuring metabolite variations reflective of malignant transformation. However, spectral contamination may affect diagnostic accuracy, impacting radiological opinion regions interest (ROI) required to determine extent surgical resection. Method A single-centre, retrospective, observational study, including 93 S...

Abstract Introduction Cognitive impairment in older Veterans is an independent predictor of subsequent mortality and disability. Pilot data indicate that patients with OSA-COPD Overlap Syndrome (OVS) may have reduced sleep quality, cognitive function quality life (QoL). However, there are no prior systematic studies evaluating treatment paradigms OVS. Our ongoing clinical trial investigating wh...