Q: Consider an uncorrelated (white) Gaussian signal s(t). Calculate its 3rd and 4th order moments, m3 = ⟨s(t1)s(t2)s(t3)⟩ and m4 = ⟨s(t1)s(t2)s(t3)s(t4)⟩. Confirm with simulation. The third moment m3 = ⟨s(t1)s(t2)s(t3)⟩ is zero. Namely, if t1 ̸= t2 ̸= t3 then m3 = ⟨s⟩ = 03 = 0. If t1 = t2 = t3, m3 = ⟨ s3 ⟩ = ́ N (0, σ2)x3dx = 0, as this is the integral over an odd function. For t1 = t2 ̸= t3, m3 = ...

Fugitive tetrachloroethylene (PCE, perc) emissions from dry cleaners operating in apartment buildings can contaminate residential indoor air. In 1997, New York State and New York City adopted regulations to reduce and contain perc emissions from dry cleaners located in residential and other buildings. As part of a New York State Department of Health (NYSDOH) study, indoor air perc levels were d...

Each subtype of the muscarinic receptor family of G protein-coupled receptors is activated by similar concentrations of the neurotransmitter acetylcholine or closely related synthetic analogs such as carbachol. However, pharmacological selectivity can be generated by the introduction of a pair of mutations to produce Receptor Activated Solely by Synthetic Ligand (RASSL) forms of muscarinic rece...

BACKGROUND Autoantibodies to the human muscarinic acetylcholine receptor of the M3 type (hmAchR M3) have been suggested to play an etiopathogenic role in Sjögren's syndrome. Primary biliary cirrhosis (PBC) often is associated with this syndrome. Therefore, we studied the co-presence of hmAchR M3 autoantibodies in patients with PBC. METHODS Frequency of hmAchR M3 autoantibodies was assessed by...

BACKGROUND Cholinergic signaling via muscarinic acetylcholine receptors (mAChR) is known to influence various physiological functions. In bone, M3 mAChR and M5 mAChR were identified on the membrane of osteoblast-like cells. M3 mAChR seems to be particularly relevant for bone physiology, as signaling via this receptor was reported to increase bone formation and decrease bone resorption. Thus, in...

Chemokine-binding proteins represent a novel class of antichemokine agents encoded by poxviruses and herpesviruses. One such protein is encoded by the M3 gene present in the murine gammaherpesvirus 68 (MHV-68) genome. The M3 gene encodes a secreted 44-kDa protein that binds with high affinity to certain murine and human chemokines and has been shown to block chemokine signaling in vitro. Howeve...

BACKGROUND The objective of this investigation was to determine the effectiveness of Canada's residential radon exposure guideline in influencing individuals' health protection decisions. METHOD Homeowners with known exposure levels in a high residential radon area (Winnipeg, Manitoba) were surveyed to document what they had done and spent to reduce their exposure to radon. The 507 respondent...

:هلاقم هصلاخ هداد حیضوت تیوضع عباوت ریداقم هلیسو هب تفج هب تفج هسیاقم هک ینامز یزاف یبتارم هلسلس لیلحترد اب یزافیراگزاس زا یفیرعت قیقحت نیا رد ،تسا هداس رایسب متسیس یراگزاس دروم رد ثحب،دوش یم ثعابو دنتسه رادروخرب یا هژیو تیمها زا یزاف یاه تبسن ،ًامازلا .دوش یم هئارا یراگزاس خرن نازیم یعضوم یاه تیولا تیوضع ریداقم اب یاه تیدودحم ناونع هب نینچمه ،دوش یم یراگزاسان خرن داجیا یدنب هبتر max-minیاه هعوم...

CD8(+) T cells restricted to MHC class Ib molecules other than H2-M3 have been shown to recognize bacterial Ags. However, the contribution of these T cells to immune responses against bacterial infection is not well defined. To investigate the immune potential of MHC class Ib-restricted CD8(+) T cells, we have generated mice that lack both MHC class Ia and H2-M3 molecules (K(b-/-)D (b-/-)M3(-/-...