PURPOSE Optimal dosing of antibiotics is important for efficacy and avoidance of resistance. Fluoroquinolones are frequently used to treat severe infections in critically ill patients. We studied ciprofloxacin pharmacokinetics after administration of 400 mg twice a day (bid) intravenously (IV). MATERIAL AND METHODS Serum concentrations were measured in 32 intensive care unit patients (age, 68...

1048 tericidal activity of ceftazidime could be correlated with the MIC value for the different strains. Results when the strains were exposed to a concentration of 4 × MIC were comparable to those at 8 × MIC, suggesting that no further bactericidal effect can be achieved by increasing the ceftazidime concentration above 4 × MIC (no concentration effect). At 2 × MIC, bactericidal activity was s...

IMPORTANCE Staphylococcus aureus bacteremia (SAB) is a worldwide problem. It is unclear whether higher-vancomycin minimum inhibitory concentration (MIC) is associated with mortality. This potential association has direct consequences for patients and public health. DATA SOURCES PubMed, Embase, the Cochrane Library, Evidence-based Medicine BMJ, and the American College of Physicians Journal Cl...

Developing interpretive breakpoints for any given organism-drug combination requires integration of the MIC distribution, pharmacokinetic and pharmacodynamic parameters, and the relationship between in vitro activity and outcome from both in vivo and clinical studies. Previously, the Subcommittee for Antifungal Testing of the Clinical and Laboratory Standards Institute (CLSI [formerly National ...