We identified discrete importation events of the mcr-1 gene on incompatibility group IncI2 plasmids in Escherichia coli isolated from patients in New South Wales, Australia, in 2011 and 2013. mcr-1 is present in a small minority of colistin-resistant Enterobacteriaceae and appears not to be established locally.

The plasma disappearance rate (metabolic clearance rate) of administered intact parathyroid hormone (intact PTH) was analyzed in awake dogs with indwelling hepatic and renal vein catheters. The metabolic clearance rate (MCR) of intact PTH was found to be very rapid, 21.6 +/- 3.1 ml/min per kg in 11 normal dogs. The liver accounted for the greatest fraction of the MCR of intact PTH (61 +/- 4%) b...

Dear Editor, Colistin is the last line of defense for carbapenem-resistant Enterobacteriaceae (CRE) or Acinetobacter baumannii infection [1]. Recently, a plasmid-mediated colistin resistance mechanism (mcr-1 gene) was identified in human, animal, and environmental isolates in China, and the worldwide spread of the mcr-1 gene has continuously been reported [2]. This colistin resistance mechanism...

Stress-induced hyperglycemia can lead to significant deterioration in glycemic control in individuals with diabetes. Previously, we have shown in normal dogs that, after intracerebroventricular (ICV) administration of carbachol (a model of moderate stress), increases in both the metabolic clearance rate (MCR) of glucose and endogenous glucose production (GP) occur. However, in hyperglycemic dia...

A two-step sequence for the synthesis of various 3,4-dihydro-2H-1,3-thiazines is presented. In the first step, 2H-1,3-thiazines were prepared by a new multicomponent reaction (MCR). Starting from β-chlorovinyl aldehydes, this MCR offers an efficient and facile access to 2,2-dialkyl- and 2-alkyl-2-aralkyl-5,6-diaryl-2H-1,3-thiazines. The potential of these products in subsequent reactions was ve...

In this contribution we give a general de nition of fairness and show how this can achieve various fairness de nitions such as those mentioned in the ATM Forum TM Speci cations We discuss how a pricing policy can be mapped to general fairness The general fairness can be achieved by calculating the ExcessFairshare for each VC We show how a switch algorithm can be modi ed to support the general f...

Aiming at semi-decentralized suburban sewage resource recovery, pilot-scale Enhanced membrane coagulation reactor (E-MCR) was set up for the first time for preliminary demonstration of sewage pre-concentration. During around 2400h continuous operation with different working scenarios, a relative stable average permeability of 30-50 L/mh·bar was achieved through the combination of enhanced coagu...

Abstract Background Entecavir (ENT) is an antiretroviral agent prescribed for the treatment of hepatitis B virus(HBV) and human immunodeficiency virus(HIV). Objective Development validation three simple, sensitive, selective, precise methods determination ENT in presence its oxidative degradation product (ENT deg.). Method The first method was based on second derivative (D2) spectrophotometry t...

Prediction using pure standards is expected to be biased whenever the slope of the calibration is affected by the presence of sample matrix. Moreover, in the presence of unknown spectral interferents, first-order algorithms like partial least squares cannot be used. In this study, a method for determination of carvedilol (CAR) in tablet and urine samples is proposed by excitation-emission fluor...