the governments of the People's Republic of China and Portugal through a contribution to the UNU Endownment Fund. As well as providing two-thirds of the endownment fund, the Macau authorities also supply UNU/IIST with its ooce premises and furniture and subsidise fellow accommodation. The mission of UNU/IIST is to assist developing countries in the application and development of software techno...

BACKGROUND We conducted a phase I-II trial to assess the feasibility and activity of a combination chemotherapy regimen with etoposide, ifosfamide, cisplatin or carboplatin, and epirubicin in limited-disease (LD, stages I-IIIB) and extensive-stage (ED, stage IV) small-cell lung cancer (SCLC). PATIENTS AND METHODS Standard-dose chemotherapy (SDC) consisting of etoposide (500 mg/m2), ifosfamide...

BACKGROUND AND OBJECTIVE Concerns about the risk of transfusion therapy are driving towards new strategies which are designed to minimize exposure to allogeneic blood products. We aimed to find out whether it is possible to support the phase of thrombocytopenia following high-dose chemotherapy (HDC) and circulating progenitor cells (CPC) transplantation by autologous platelet concentrates (PC)....

High-dose chemotherapy (HDC) conditioning given in association with autologous stem cell transplantation (ASCT) or reduced-intensity conditioning (RIC) with allogeneic stem cell transplantation (alloSCT) are established treatment approaches for patients with chemotherapy-sensitive, relapsed, aggressive, or low-grade non-Hodgkin's lymphoma (NHL). These approaches have been shown to be the only c...

Human dendritic cells (hDCs) produce IL-2 and express IL-2R α-chain (CD25), but the role of IL-2 in DC functions is not well defined. A recent study suggested that the main function of CD25 on hDCs was to transpresent IL-2 to activate T lymphocytes. Our results demonstrate the expression of the three chains of the IL-2R on hDCs and that IL-2 induces STAT5 phosphorylation. Interestingly, use of ...

OBJECTIVES To look at trends in generalised (body mass index (BMI) >or=30 kg m(-2)) and abdominal (waist circumference (WC) >102 cm in men, >88 cm in women) obesity among adults between 1993 and 2003, and to evaluate their association with diabetes, hypertension and hypertension-diabetes co-morbidity (HDC) in England. DESIGN Analyses of nationally representative cross-sectional population sur...

To determine the respective role played by orexin/hypocretin and histamine (HA) neurons in maintaining wakefulness (W), we characterized the behavioral and sleep-wake phenotypes of orexin (Ox) knock-out (-/-) mice and compared them with those of histidine-decarboxylase (HDC, HA-synthesizing enzyme)-/- mice. While both mouse strains displayed sleep fragmentation and increased paradoxical sleep (...

Bridge condition assessment (BCA) plays an important role in modern bridge management. Existing methods are time-consuming, labor-intensive and error-prone. The use of machine learning for BCA can effectively solve the above problems. However, large amount label noise dataset severely affected performance model. In this paper, we present effective ranking approach (LR-BCA). Our proposed LR-BCA ...

Chlamydomonas reinhardtii (C. reinhardtii) has a potential as novel source for food/feed because it contains several constituents including bioactive compounds. However, its multilayer cell wall (hydroxyproline-rich glycoprotein [HRPGs]) may restrict the bioaccessibility of nutrients. Therefore, using disruption techniques such hydrodynamic cavitation (HDC) can be useful assessing single This w...