OBJECTIVES To determine if maternal serum levels of 25(OH)D at 11-13 weeks' gestation are altered in pregnancies that subsequently deliver small for gestational age (SGA) neonates and whether the levels are related to placental function reflected in serum concentration of pregnancy-associated plasma protein-A (PAPP-A). METHODS Serum 25(OH)D and PAPP-A were measured at 11-13 weeks in 150 singl...

The bacteriophage Mu mom gene encodes the unique DNA-modification function of the phage. Regulation of the mom gene at the transcriptional level is brought about by the transactivator protein C of the phage. The mom promoter is an activator-dependent weak promoter having poor -10 and -35 elements separated by a 19 bp suboptimal spacer region. These features could constrain RNA polymerase occupa...

This paper presents techniques for optimizing the performance of FEM/MoM codes. The process of computing MoM matrices can be accelerated by choosing the order of Gaussian Quadrature calculations adaptively and taking advantage of the symmetric nature of the impedance (or admittance) matrix. Optimizing loop index order and buffering loop indices can significantly improve the performance of matri...

Varieties of Message-Oriented Middleware (MOM) platforms are available each with their own propriety functionality to solve specific messaging challenges. At present, it is not possible to mix and match these propriety features into a customized MOM solution. A number of patterns have been identified that allow a software systems implementation to be more flexible and extensible. This work inve...

This paper is the first in a series whose goal is to understand the structure of low-volume complete orientable hyperbolic 3-manifolds. Here we introduce Mom technology and enumerate the hyperbolic Mom-n manifolds for n ≤ 4. Our longterm goal is to show that all low-volume closed and cusped hyperbolic 3-manifolds are obtained by filling a hyperbolic Mom-n manifold, n ≤ 4 and to enumerate the lo...

OBJECTIVES Our primary objective was to determine the association of maternal serum analytes in pregnancies complicated by intrauterine growth restriction (IUGR) stratified by umbilical artery (UA) Doppler versus pregnancies with appropriately grown for gestational age (AGA) and its potential use as screening model. METHODS Retrospective cohort evaluating first and second trimester maternal s...

OBJECTIVE To examine the potential value of maternal serum concentration of placental protein 13 (PP13) at 11-13 weeks' gestation in screening for preeclampsia (PE). METHODS Serum PP13, PAPP-A and uterine artery pulsatility index (PI) were determined in a case-control study of 208 cases that developed PE including 48 that required delivery before 34 weeks (early-PE) and 416 unaffected control...

PURPOSE/OBJECTIVES To examine the experiences of being parented when mothers are diagnosed and treated for breast cancer from the perspectives of adolescent daughters. RESEARCH APPROACH Empirical phenomenologic. SETTING Participants were recruited from sites in Indiana and Arizona. PARTICIPANTS Eight adolescent daughters whose mothers had been diagnosed with and treated for breast cancer....

OBJECTIVE To assess the impact of a vanishing twin on the levels of the biochemical markers used in the first trimester aneuploidy screening. METHODS A retrospective analysis of free beta-hCG and PAPP-A levels in 270 women with a normal singleton fetus with ultrasound evidence of a vanishing twin pregnancy. Marker levels (as MoM) were compared in three groups-76 women with a second empty gest...

OBJECTIVES To establish reference ranges for middle cerebral artery peak systolic velocity (MCA PSV) and to certify their value in the management of Rhesus alloimmunized pregnancies. MATERIAL AND METHODS A reference range of MCA PSV with gestation was constructed by studying 342 pregnancies at 25-40 weeks. A comparison was made between the reference ranges produced in our study and those alre...