نتایج جستجو برای: روش شبهطیفی tau
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and |V[subscript us]| Using Tau Lepton Decays to e-[over-bar]etau, mu-[over-bar]mu, pi-tau, and K-tau Citation BABAR Collaboration et al. " Measurements of Charged Current Lepton Universality and |V_{us}| Using Tau Lepton Decays to e^{-} nu [over-bar]_{e} nu _{ tau }, mu^{-} nu [over-bar]_{mu} nu _{ tau }, pi^{-} nu _{ tau }, and K^{-} nu _{ tau }. Article is made available in accordance with t...
While the interneuronal propagation of neurofibrillary lesions in Alzheimer's disease and other tauopathies now appears to involve the spreading of tau-associated toxicity, little is known about its mechanism. We characterized the movement of human tau through the brain of a non-transgenic lower vertebrate tauopathy model in which full-length wild type and mutant human tau isoforms were express...
The neuritic plaque facilitates pathological conversion of tau in an Alzheimer's disease mouse model
A central question in Alzheimer's Disease (AD) is whether the neuritic plaque is necessary and sufficient for the development of tau pathology. Hyperphosphorylation of tau is found within dystrophic neurites surrounding β-amyloid deposits in AD mouse models but the pathological conversion of tau is absent. Likewise, expression of a human tau repeat domain in mice is insufficient to drive the pa...
Tau aggregation occurs in neurodegenerative diseases including Alzheimer's disease and many other disorders collectively termed tauopathies. trans-cellular propagation of tau pathology, mediated by extracellular tau aggregates, may underlie pathogenesis of these conditions. P301S tau transgenic mice express mutant human tau protein and develop progressive tau pathology. Using a cell-based biose...
هدف: هدف از انجام این پژوهش مقایسه اثربخشی طرح‌واره‌درمانی و واقعیت‌درمانی بر انعطاف‌پذیری روان‌شناختی خودتنظیمی هیجانی مربیان پیش‌دبستانی شهرستان شهرکرد بود. روش: جامعه آماری کلیة شهرکردبودند که بین آنها تعداد 45 نفر به صورت نمونه‌گیری در دسترس انتخاب گمارش تصادفی 2 گروه آزمایش و1 کنترل (هر کدام 15 نفر) گمارده شدند. ابزار اندازه‌گیری شامل پرسشنامه‌های (بوند همکاران، 2011) هیجانی(مارس، 1983) بو...
Previous studies indicate an important role for the cellular prion protein (PrP(C)) in the development of Alzheimer's disease (AD) pathology. In the present study, we analyzed the involvement of PrP(C) in different pathological mechanisms underlying AD: the processing of the amyloid-β protein precursor (AβPP) and its interaction with AβPP, tau, and different phosphorylated forms of the tau prot...
Tau is a key protein in the pathogenesis of various neurodegenerative diseases, which are categorized as tauopathies. Because the extent of tau pathologies is closely linked to that of neuronal loss and the clinical symptoms in Alzheimer's disease, anti-tau therapeutics, if any, could be beneficial to a broad spectrum of tauopathies. To learn more about tauopathy, we developed a novel transgeni...
Both Alzheimer's disease (AD) and frontotemporal dementia (FTD) are characterized by the deposition of hyperphosphorylated forms of the microtubule-associated protein tau in neurons and/or glia. This unifying pathology led to the umbrella term "tauopathies" for these conditions, also emphasizing the central role of tau in AD and FTD. Generation of transgenic mouse models expressing human tau in...
Mutations in the gene encoding tau cause frontotemporal dementia with parkinsonism--chromosome 17 type (FTDP-17). In FTDP-17, Alzheimer's disease, and other tauopathies, aggregated hyper-phosphorylated tau forms the neurofibrillary tangles characteristic of these disorders. We previously reported a Caenorhabditis elegans model for tauopathies using human normal and FTDP-17 mutant tau as transge...
We calculate the firing rate of the quadratic integrate-and-fire neuron in response to a colored noise input current. Such an input current is a good approximation to the noise due to the random bombardment of spikes, with the correlation time of the noise corresponding to the decay time of the synapses. The key parameter that determines the firing rate is the ratio of the correlation time of t...
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