Tuberculosis (TB) can involve any organ system in the body. Extrapulmonary involvement can occur in isolation or along with a pulmonary focus as in the case of patients with disseminated tuberculosis. Tuberculosis meningitis (TBM) is the most severe form of extrapulmonary tuberculosis. TBM a medical emergency, is still a major cause of serious illness in many parts of the world. TBM remains dif...

one of the most important parameters used for determining the performance of tunnel boring machines (tbms) is their penetration rate. the parameters affecting the penetration rate can be divided in two categories. the first category is the controllable parameters such as the tbm technical characteristics, and type and geometry of the tunnel, and the second one is the uncontrollable parameters s...

The study takes into account different classes of tunnel boring machines (TBM), with the aim identifying correlation models which are meant to estimate, at a preliminary design phase, construction time and evaluate mechanical operational parameters TBMs, starting from knowledge length excavation diameter. To achieve this goal, first all database was created, thanks collection most meaningful te...

Cortical venous thrombosis (CVT) mostly occurs due to a hypercoagulable state. Infection- related CVT is very rare and medical emergency associated with high mortality rate. It has been described bacterial fungal infections; but only few isolated case reports of tubercular meningitis (TBM) exist. Only six documentations CVT, as complication TBM, exist in the literature. Here, we report young gi...

A dysregulated host immune response significantly contributes to morbidity and mortality in tuberculous meningitis (TBM). Effective directed therapies (HDTs) are critical improve survival clinical outcomes. Currently only one HDT, dexamethasone, is proven mortality. However, there no evidence dexamethasone reduces morbidity, how it uncertain, has benefit HIV co-infected individuals. Furt...

The sensitivity and specificity of immunocytochemical staining of mycobacterial antigens in the cytoplasm of cerebrospinal fluid (CSF) macrophages for diagnosis of tuberculous meningitis (TBM) was prospectively compared with Ahuja criteria from 393 consecutive CSF specimens. The assay can play an important role for the diagnosis of TBM, with sensitivity of 73.5% and specificity of 90.7%.

Unlike in pulmonary multidrug-resistant (MDR) tuberculosis, the clinical outcome of MDR tuberculous meningitis (TBM) in children, including extensively drug-resistant tuberculosis, is poor and management is challenging. We report the successful treatment of a case of extensively drug-resistant TBM in a 4-year-old girl, and we discuss implications for tuberculosis diagnosis and chemotherapy.

Fifty-three cerebrospinal fluid specimens from meningitis patients were investigated by enzyme-linked immunosorbent assay for detection of mycobacterial antigens. After heating at 56 degrees C for 1 hour to eliminate nonspecific interference, all 22 tuberculous meningitis (TBM) specimens had an optical density of greater than 0.05 (sensitivity 100%). Six out of 31 non-TBM cases gave false-posit...

A new theoretical/empirical model has been developed for performance prediction of hard rock TBMs. The model uses information on the rock properties and cutting geometry to calculate TBM rate of penetration. The model can also be used for TBM butterhead design optimization to achieve maximum performance in a given geology.