disorders that may dramatically affect cognitive and social competence (e.g. Alzheimer’s disease, dyslexia, autism, attention-deficit–hyperactivity disorder, Parkinson’s disease) are mainly attributable to neurochemical imbalances, such as aberrant dopaminergic activity.5 This imbalance may well explain various symptoms of DCD, such as difficulties in handwriting, language, motor planning, and ...

The aim of this study is to describe the reaching action of children with developmental coordination disorder (DCD) and to investigate whether their use of visual feedback during the time course of this action differs from that of normally developing children. Fifty-two children subdivided into 2 age bands (7-8 and 9-10 years) within 2 groups (with and without DCD) participated in this experime...

With the rapid increases in processor speed, disk I/Os will eventually become a system bottleneck. We have recently proposed a new disk I/O architecture called DCD (Disk Caching Disk) that can drastically improve disk I/O write performance as shown by simulation experiments [2,4]. To validate whether DCD can live up to its promise in the real world, this paper presents a design and implementati...

Mitochondria within cultured rat cerebellar granule cells have a complex influence on cytoplasmic free Ca2+ ([Ca2+]c) responses to glutamate. A decreased initial [Ca2+]c elevation in cells whose mitochondria are depolarized by inhibition of the ATP synthase and respiratory chain (conditions which avoid ATP depletion) was attributed to enhanced Ca2+ extrusion from the cell rather than inhibited ...

OBJECTIVE There is increasing evidence to suggest that developmental dyslexia (DD) and developmental coordination disorder (DCD) actually form part of a broader disorder. Their frequent association could be justified by a deficit of the procedural memory system, that subtends many of the cognitive, motor and linguistic abilities that are impaired in both DD and DCD. However, studies of procedur...

A dysfunction in predictive motor timing is put forward to underlie DCD-related motor problems. Predictive timing allows for the pre-selection of motor programmes (except 'program' in computers) in order to decrease processing load and facilitate reactions. Using functional magnetic resonance imaging (fMRI), this study investigated the neural correlates of motor timing in DCD (n=17) and typical...

(see NEWSBRIEFS on p. 8) R at the Beckman Laser Institute have scored a major success in the area of technology transfer with the licensing and marketing of a patented cooling device used for many of the most common laser-based medical procedures. The Dynamic Cooling DeviceTM (DCD), which provides rapid and spatially selective cooling of the epidermis during laser treatments for a variety of sk...

Cerebral visual impairment (CVI) has become the primary cause of visual impairment and blindness in children in industrialized countries. Its prevalence has increased sharply, due to increased survival rates of children who sustain severe neurological conditions during the perinatal period. Improved diagnosis has probably contributed to this increase. As in adults, the nature and severity of CV...

Excitotoxicity is the process whereby a massive glutamate release in the central nervous system in response to ischaemia or related trauma leads to the delayed, predominantly necrotic death of neurons. Excitotoxicity is also implicated in a variety of slow neurodegenerative disorders. Mitochondria accumulate much of the post-ischaemic calcium entering the neurons via the chronically activated N...

Cerebral contusions are one the most frequent traumatic lesions and the most common indication for secondary surgical decompression. The purpose of this study was to investigate the physiology of perilesional secondary brain damage and evaluate the value of hyperbaric oxygen therapy (HBOT) in the treatment of these lesions. Five groups of five Sprague-Dawley rats each were submitted to dynamic ...