Abnormalities of intestinal calcium absorption and the vitamin D axis in the spontaneously hypertensive rat (SHR) are controversial. The present report documents a reduction in circulating 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) in the 12-14-wk-old male SHR with evidence of its functional significance. Both plasma 1,25(OH)2D3 and mucosa-to-serosa duodenal calcium flux (Jm-s), measured by the Uss...

INTRODUCTION Age and hypertension are two major determinants of arterial stiffness, as well as endothelial dysfunction. The present study was designed to test whether a chronic reduction of endogenous nitric oxide (NO) produces arterial stiffening close to that observed in old spontaneously hypertensive rats (SHR), and also to study the effect of an acute or a chronic decrease in blood pressure...

هدف: سکوت سازمانی پدیده‌­ای رایج و متداول در سازمان­‌ها واقعیتی موجود ملموس برای مدیران کارکنان است. یکی از موانع مهم موفقیت برنامه‌­ها اهداف سازمان، فقدان اطلاعات، اعتماد آن چیزی است که پژوهشگران را نام نهاده‌­اند عبارت خودداری بیان ایده‌­ها، نظرات اطلاعات راجع به مشکلات سازمانی. سویی دیگر قصد ترور روحی با ایجاد فشار روانی روی شخص مورد هدف، دورکردن هویت استفاده فشارهای منظم مستمراست. توجه اینک...

Gas hydrates are likely to become an important strategic resource with commercial development prospects. It is therefore of great significance realize the long-term and efficient production methane hydrate reservoirs. Previous studies have shown that lithological characteristics reservoirs a significant impact on reservoir productivity by influencing evolution seepage parameters in process prod...

BACKGROUND Obesity has been strongly associated with the development and aggravation of hypertension and chronic kidney disease. To date, the systemic renin-angiotensin system (RAS) has been known to involve in obesity-induced tissue damage and hypertension. However, the intrarenal mechanism whereby obesity induces and aggravates hypertension and renal disease remains poorly understood. Therefo...

OBJECTIVE We investigated whether angiotensin II (Ang II)-induced reactive oxygen species (ROS) generation is altered in vascular smooth muscle cells (VSMCs) from spontaneously hypertensive rats (SHR) during the phases of prehypertension, developing hypertension, and established hypertension and assessed the putative role of insulinlike growth factor-1 receptor (IGF-1R) in Ang II-mediated actio...

BACKGROUND Although obesity has been associated with several effects in rodents, few investigations have evaluated the metabolic, endocrine, and cardiac parameters of spontaneously hypertensive rats (SHR) with dietary-induced obesity. The current study analyzed the influence of dietary-induced obesity on metabolic, endocrine, and cardiac characteristics in SHR. MATERIAL/METHODS Male SHR were ...

BACKGROUND & OBJECTIVES A wealth of information concerning the essential role of renal sympathetic nerve activity (RSNA) in the regulation of renal function and mean arterial blood pressure homeostasis has been established. However, many important parameters with which RSNA interacts are yet to be explicitly characterized. Therefore, the present study aimed to investigate the impact of acute re...

The activity and protein expression of endothelial nitric oxide synthase (eNOS) and inducible NOS (iNOS) were investigated during the development of hypertension in spontaneously hypertensive rats (SHR). SHR and Wistar-Kyoto rats (WKY) were studied at three different ages: 4, 14 to 17, and 63 weeks of age. After treatment with saline or lipopolysaccharide (LPS, 10 mg/kg IV) for 3 hours, the aor...