Psoriasis is a chronic immune-mediated disorder that has a substantial impact on quality of life (1). It is characterized by systemic inflammation and cytokine dysregulation. In particular, alterations in T helper (Th) 1, Th17, and Th22 cells drive this disease with elevated serum concentrations of multiple proinflammatory cytokines, including TNF, IL-6, and IL-8 (1). Thus, monoclonal antibodie...

The aim of this study was to examine the relationship between measures of disease severity and costs from a societal perspective in patients with plaque psoriasis. Dermatologists in Sweden recruited 443 consecutive patients who had had no biological treatment during the past 12 months. Following a Psoriasis Area and Severity Index (PASI) assessment, subjects completed self-assessments on health...

Psoriasis is a chronic inflammatory skin disease characterized by alterations in cytokines produced by both Th1 and Th17 pathways. The aim of this study was to evaluate serum levels of pivotal cytokines and correlate them with clinical parameters. Serum samples from 53 psoriasis patients and 35 healthy volunteers, matched by the proportion of sex and age ratios, were collected for ELISA cytokin...

Neopterin is a non-specific marker of the activation of cell-mediated immunity. Several studies have demonstrated the crucial role of CD4+ T cells in the pathogenesis of psoriasis. We have measured serum and urine neopterin levels and urine neopterin/creatinine ratios by radioimmunoassay in 24 patients with plaque-type psoriasis before and after a course of topical treatment with triamcinolone ...

background: psoriasis is a common chronic and relapsing skin disease with unknown etiology being observed at any age and any gender, having a 1. 5-3% prevalence rate among the general population. psoriatic lesions consist of pruritic and scaling papules, residing on an erythematous base, which are more commonly found on the scalp, extensor surfaces, palms and soles, and the nails. the conventio...

Purpose: Psoriasis is a chronic, inflammatory, and systemic disease. The disease activity usually measured by Area Severity Index (PASI), however, further objective laboratory tools are needed. Neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte (PLR) mean platelet volume (MPV) objectively calculated markers that increase in inflammation. This study aimed to investigate the utility of these ...

INTRODUCTION Psoriasis is a chronic skin ailment which can be connected with an increased occurrence of other illnesses, including high blood pressure. EXAMINEES AND METHODS A prospective study has been conducted which included 70 patients affected by psoriasis, both genders, older than 18 years. Average age being 47,14 (SD= ±15,41) years, from that there were 36 men or 51,43 and 34 women or ...