The glycan moiety of ganglioside HPG-7, isolated from the sea cucumber (Holothuria pervicax), was synthesized for the first time. The characteristic substructure, a trisialic acid sequence embedded in the glycan, was deliberately constructed by utilizing suitably differentiated sialyl units for various synthetic purposes. Finally, a pentasaccharide was successfully delivered as the hexyl glycos...

The experiment recorded in this note was undertaken in 1917, with a view to testing the notion (Crozier, 1914-15) that the fluorescent, greenish yellow, integumentary pigment characteristic of some members of the genus ttolothuria is concerned with their photic sensitivity. A functional connection of this sort was suspected because the presence and relative amount of the pigment seemed to be co...

objective(s):marine organisms are known as a potential source of natural products, which contain bioactive substances with therapeutic properties. sea cucumbers are prominent among marine organisms because of their dietary and therapeutic applications. in addition, they have capacity of synthesizing saponins molecules and other metabolites with therapeutic properties such as antitumor, antimicr...

In Holothuria polii, the periesophageal ring is an important organ supplying spherule cells after stimulation with foreign material. In animals injected with formalinized sheep erythrocytes, in fact, a depletion of spherule cells is observed in the periesophageal ring, whereas in the connective tissue, in the external epithelium and around the antigen-injected site, small, transparent cells can...

In September 1975, 5031 sea cucumbers (Holothuria atra Jager) were tagged with tetracycline and returned to a gutter on the seaward reef bench of Ananij Island, Enewetak Atoll, Marshall Islands. A sample of 184 individuals was collected in September 1976. Animals were dissected and plates of the calcareous ring were examined with ultraviolet radiation for tetracycline lines. Based on 18 tagged ...