The calcyclin binding protein and Siah-1 interacting protein (CacyBP/SIP) protein was shown to play a role in the organization of microtubules. In this work we have examined the neuronal distribution and possible function of CacyBP/SIP in cytoskeletal pathophysiology. We have used brain tissue from Alzheimer's disease (AD) patients and from transgenic mice modeling 2 different pathologies chara...

A SIP server may be overloaded by emergency-induced call volume, “American Idol” style flash crowd effects or denial of service attacks. The SIP server overload problem is interesting especially because the cost of serving and rejecting a SIP session could be in the same neighborhood. For this reason, the built-in SIP overload control mechanism based on generating rejection messages could not p...

Ubiquitous worldwide broadband Internet access as well the coming of age of VoIP technology have made Voice-over-IP an increasingly attractive and useful network application. Currently the “human-readable” Session Initiation Protocol (SIP) which is based on a simple HTTP-like request/response exchange is steadily gaining headway against the considerably more complex ASN.1 encoded H.323 Multimed...

This paper describes methods for implementing telephony services in SIP with fewer traditional feature interactions. A formal SDL model of SIP and its services has been derived from published SIP specifications for verification and validation. It is known that the SIP RFC describes only the protocol specification. The specifications of SIP services and additional service features are informal a...

CacyBP/SIP is a component of the ubiquitin pathway and is overexpressed in several transformed tumor tissues, including colon cancer, which is one of the most common cancers worldwide. It is unknown whether CacyBP/SIP promotes the proliferation of colon cancer cells. This study examined the expression level, subcellular localization, and binding activity of CacyBP/SIP in human colon cancer cell...

There are various ways to control a computer, but today the mouse function, to move a cursor and to perform a click function, is essential. For motion-disabled persons, especially persons with high spinal cord injuries, special aids are needed to perform these interactions. In this study, an alternative way to perform a click function has been investigated, the sip-and-puff function. The purpos...