An increasing rate of infections with Shiga toxin/verotoxin-producing Escherichia coli (STEC/VTEC) O104:H4 has been observed in Germany since May 2011, with unusually high numbers of patients suffering from haemolytic uraemic syndrome (HUS). We report a STEC/VTEC O104:H4 case without HUS, presenting with colonic ischaemia demanding surgery. This atypical clinical presentation of STEC O104:H4 in...

<h4>Penelitian ini dilakukan untuk mendeskripsikan bahasa Minangkabau yang mengalami penghilangan (<em>omission</em>) serta perubahannya. Penelitian menggunakan metode deskriptif kualitatif. Data dalam penelitian berupa tuturan kata-kata Minangkabau. Sumber data adalah seorang penutur berasal menguasai di Cipadu. dikumpulkan teknik pancing, wawancara, rekam, simak dan catat. B...

OBJECTIVE Autoimmune diabetes is a T cell-mediated disease in which insulin-producing β-cells are destroyed. Autoreactive T cells play a central role in mediating β-cell destruction. B7-H4 is a negative cosignaling molecule that downregulates T-cell responses. In this study, we aim to determine the role of B7-H4 on regulation of β-cell-specific autoimmune responses. RESEARCH DESIGN AND METHOD...

Purpose: Cancers have developed a number of strategies to escape immune responses including the differential expression of costimulatory molecules of the B7 family. B7-H3 and B7-H4 have recently been described in different tumor entities but the relevance for melanoma has not yet been studied so far. Experimental Design: Using immunohistochemistry, B7-H3 and B7-H4 expression was studied on 29 m...

This study aimed to identify N-acylhomoserine lactone (AHL) produced by Hafnia alvei H4, which was isolated from spoiled instant sea cucumber, and to investigate the effect of AHLs on biofilm formation. Two biosensor strains, Chromobacterium violaceum CV026 and Agrobacterium tumefaciens KYC55, were used to detect the quorum sensing (QS) activity of H. alvei H4 and to confirm the existence of AH...

The aim of the present study was to investigate the expression of B7-H1 and B7-H4 in ovarian neoplasm tissues and to examine their clinical relevance. A total of 112 ovarian biopsies were collected from patients with epithelial ovarian cancer (EOC) and 10 were taken from ovarian benign neoplasms. The samples were processed in paraffin tissue chips, and subjected to immunohistochemical staining ...

several of the histone fold helices in free H3.3/H4 complexes. In sum, we have found that DAXX stabilizes a pre-nucleosomal folded form of H3.3/H4 that differs from its final nucleosome form or its form free in solution. While the steps in the folding pathway we studied are certainly tied to the mechanism of chromatin assembly, so to is the massive destabilization we predict occurs to DAXX [HBD...

The H4 technique facilitates text entry with key sequences created using Huffman coding. This study evaluates the use of touch and motion-sensing gestures for H4 input. Touch input yielded better entry speeds (6.6 wpm, versus 5.3 wpm with motion-sensing) and more favourable participant feedback. Accuracy metrics did not differ significantly between the two conditions. Changes to the H4 techniqu...

Protein N(α)-terminal acetylation (Nt-acetylation) is considered one of the most common protein modification in eukaryotes, and 80-90% of all soluble human proteins are modified in this way, with functional implications ranging from altered protein function and stability to translocation potency amongst others. Nt-acetylation is catalyzed by N-terminal acetyltransferases (NATs), and in yeast fi...