BACKGROUND Syphilis infection during pregnancy leads to avoidable morbidity and mortality and remains a significant problem in sub-Saharan Africa. Despite global initiatives to increase the proportion of pregnant women screened, implementation has been slow. We sought to investigate the feasibility of adding syphilis screening within an integrated antenatal HIV clinic. METHODS Pregnant women ...

RNase P catalyzes the Mg(2)(+)-dependent 5'-maturation of precursor tRNAs. Biochemical studies on the bacterial holoenzyme, composed of one catalytic RNase P RNA (RPR) and one RNase P protein (RPP), have helped understand the pleiotropic roles (including substrate/Mg(2+) binding) by which a protein could facilitate RNA catalysis. As a model for uncovering the functional coordination among multi...

A pulse of the steroid hormone ecdysone triggers the destruction of larval salivary glands during Drosophila metamorphosis through a transcriptional cascade that converges on reaper (rpr) and head involution defective (hid) induction, resulting in caspase activation and cell death. We identify the CREB binding protein (CBP) transcriptional cofactor as essential for salivary gland cell death. We...

Independently folded domains in RNAs frequently adopt identical tertiary structures regardless of whether they are in isolation or are part of larger RNA molecules. This is exemplified by the P15 domain in the RNA subunit (RPR) of the universally conserved endoribonuclease P, which is involved in the processing of tRNA precursors. One of its domains, encompassing the P15 loop, binds to the 3'-e...

Given a general 3-RPR planar parallel robot with linear platforms, it is proven that there are no singularity-free paths between non-symmetrical direct kinematics solutions. We provide an alternative proof of this. also shows path two symmetrical solutions if appropriate condition satisfied. This will be automatically satisfied for exactly one pair four real to the kinematics. The topology kine...

venereal diseases are still a common problem in today's world. even though tremendous advances are being made in medicine and large budgets are being spent to control sexually transmitted diseases (std), especially in western countries, these diseases are still yet very common, and today aids has been added to the threats posed by std to human life. the status of syphilis was evaluated in ...

The Resilient Packet Ring (RPR) IEEE 802.17 standard is under development as a new high-speed backbone technology for metropolitan area networks. A key performance objective of RPR is to simultaneously achieve high utilization, spatial reuse, and fairness, an objective not achieved by current technologies such as SONET and Gigabit Ethernet nor by legacy ring technologies such as FDDI. The core ...

During insect metamorphosis, pulses of the steroid hormone 20-hydroxyecdysone (ecdysone) direct the destruction of obsolete larval tissues and their replacement by tissues and structures that form the adult fly. We show here that larval midgut and salivary gland histolysis are stage-specific steroid-triggered programmed cell death responses. Dying larval midgut and salivary gland cell nuclei be...

OBJECTIVES The objective of this study was to characterize syphilis epidemiology and the relationship of HIV status and initial rapid plasma reagin (RPR) titer to syphilis treatment in Lima, Peru. STUDY DESIGN We screened 1,261 individuals at high risk for sexually transmitted diseases for syphilis and HIV infection. Syphilis was treated with penicillin injection or doxycycline; treatment was...

OBJECTIVES To determine the costs of Rapid Syphilis Test (RSTs) as compared with rapid plasma reagin (RPR) when implemented in a Tanzanian setting, and to determine the relative impact of a quality assurance (QA) system on the cost of RST implementation. METHODS The incremental costs for RPR and RST screening programmes in existing antenatal care settings in Geita District, Tanzania were coll...