MicroRNA-147 (miR-147) had been previously found induced in synoviocytes by inflammatory stimuli derived from T cells experimental arthritis. This study was designed to verify whether loss of its function might alleviate events joints and rheumatoid arthritis (RA). Dark Agouti (DA) rats were injected intradermally with pristane induce arthritis, rno-miR-147 antagomir locally administrated into ...

Abstract Background Emerging evidence suggests that epithelial cell-derived microRNAs (miRNA) are involved in the pathogenesis of inflammatory bowel disease; however, as now specific implications real clinical practice, especially relation to biologics use yet far-fetched. Therefore, we tried investigate cell derived miRNA signatures related and endoscopic activity Crohn’s disease (CD) patients...

Background and Objective: Ulcerative colitis (UC) is an unknown recurrent intestinal disease and a common cause of gastrointestinal disorders, which may lead to colorectal cancer if not diagnosed and treated in a timely manner. The beneficial effects of several probiotics in diseases like inflammatory bowel disease (IBD) have been investigated, although their mechanisms have not been yet fully ...

Background: Gastric cancer is among the most common malignancies in certain parts of the world, such as northwest Iran. miRNAs are small and single-stranded noncoding RNAs with about 19-23 nucleotides. Several studies have shown that miRNAs play important roles in gastric tumorigenesis. The aim of this study was to determine the effect of miRNA-1266-5p repression on the cell survival and altera...

A local luminosity function at 15µm is derived using the bivariate (15µm vs. 60µm luminosity) method, based on the newly published ISOCAM LW3-band (15µm) survey of the very deep IRAS 60µm sample in the north ecliptic pole region (NEPR). New IRAS 60µm fluxes are obtained using the SCANPI/SUPERSCANPI software at the new ISOCAM positions of the sources in the sample. It is found to be in excellent...

Abstract Esophageal cancer (EC) including esophageal squamous cell carcinoma (ESCC) and adenocarcinoma (EAC) generally exhibits poor prognosis; hence, a noninvasive biomarker enabling early detection is necessary. Age- sex-matched 150 healthy controls (HCs) 43 patients with ESCC were randomly divided into two groups: 9 individuals in the discovery cohort for microarray analysis 184 training/tes...