Pyrazole treatment to induce cytochrome P-450 2E1 (CYP2E1) was recently shown to cause liver injury in ob/ob mice but not in lean mice. The present study investigated the effects of S-adenosyl-l-methionine (SAM) on the CYP2E1-dependent liver injury in ob/ob mice. Pyrazole treatment of ob/ob mice for 2 days caused necrosis, steatosis, and elevated serum transaminase and triglyceride levels compa...

Riboswitches are RNA elements that allosterically regulate gene expression by binding cellular metabolites. The SAM-III riboswitch, one of several classes that binds S-adenosylmethionine (SAM), represses translation upon binding SAM (OFF state) by encrypting the ribosome binding sequence. We have carried out simulations of the RNA by applying mechanical force (f) to the ends of SAM-III, with an...

BACKGROUND Malnutrition is one of the leading causes of morbidity and mortality among children under the age of 5 years in low and middle income countries like Nepal. Children with severe acute malnutrition (SAM) are nine times more likely to die than children without malnutrition. The prevalence of SAM has increased in Nepal over the past 15 years; however, the determinants of SAM have not bee...

The SAM-Grid system is an integrated data, job, and information management infrastructure. The SAM-Grid addresses the distributed computing needs of the experiments of RunII at Fermilab. The system typically relies on SAM-Grid services deployed at the remote facilities in order to manage computing resources. Such deployment requires special agreements with each resource provider and it is a lab...

BACKGROUND Self-administration of medicines is believed to increase patients' understanding about their medication and to promote their independence and autonomy in the hospital setting. The effect of inpatient self-administration of medication (SAM) schemes on patients, staff and institutions is currently unclear. OBJECTIVE To systematically review the literature relating to the effect of SA...

This paper describes the design and evaluation of SAM, a shared object system for distributed memory machines. SAM is a portable run-time system that provides a global name space and automatic caching of shared data. SAM incorporates mechanisms to address the problem of high communication overheads on distributed memory machines; these mechanisms include tying synchronization to data access, ch...

S-Adenosylmethionine synthetase (SAM synthetase) catalyzes the synthesis of S-adenosylmethionine (SAM), which plays an important role in cellular functions such as methylation, sulfuration, and polyamine synthesis. To develop a simple and effective way to enzymatically synthesize and produce SAM, a soluble form of SAM synthetase encoded by SAM2 from Saccharomyces cerevisiae was successfully pro...

Among the 20 subfamilies of protein receptor tyrosine kinases (RTKs), Eph receptors are unique in possessing a sterile alpha motif (SAM domain) at their C-terminal ends. However, the functions of SAM domains in Eph receptors remain elusive. Here we report on a combined cell biology and quantitative fluorescence study to investigate the role of the SAM domain in EphA2 function. We observed eleva...

Social accounting matrices (SAMs) have been used fairly extensively to model the effects of shocks on a nation's economy. A brief literature review on SAMs and examples of their use for simple simulations were provided by Parra and Wodon (2009b) in chapter 6 of this volume. That chapter highlighted the strengths and weaknesses of SAMs and emphasized the need to be care­ ful before using SAM-bas...

T paper describes a decision tree analysis to assess the cost-effectiveness of MANPADS (Man-Portable Air Defense Systems) countermeasures. These countermeasures are electronic devices that can be installed on commercial airplanes to detect and deflect surface-to-air missiles (SAMs) fired by terrorists. The model considers a terrorist attempt to shoot down a commercial airplane with a heat-seeki...